ID A0A0V0TKE0_9BILA Unreviewed; 394 AA.
AC A0A0V0TKE0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-NOV-2024, entry version 20.
DE RecName: Full=GPI mannosyltransferase 1 {ECO:0000256|ARBA:ARBA00013797, ECO:0000256|RuleBase:RU365064};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU365064};
DE AltName: Full=GPI mannosyltransferase I {ECO:0000256|RuleBase:RU365064};
DE Flags: Fragment;
GN Name=Pigm {ECO:0000313|EMBL:KRX39481.1};
GN ORFNames=T05_931 {ECO:0000313|EMBL:KRX39481.1};
OS Trichinella murrelli.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=144512 {ECO:0000313|EMBL:KRX39481.1, ECO:0000313|Proteomes:UP000055048};
RN [1] {ECO:0000313|EMBL:KRX39481.1, ECO:0000313|Proteomes:UP000055048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS417 {ECO:0000313|EMBL:KRX39481.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-
CC acyl-PI during GPI precursor assembly. {ECO:0000256|ARBA:ARBA00025668,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365064}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- SIMILARITY: Belongs to the PIGM family. {ECO:0000256|ARBA:ARBA00011071,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRX39481.1}.
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DR EMBL; JYDJ01000232; KRX39481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V0TKE0; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000055048; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990529; C:glycosylphosphatidylinositol-mannosyltransferase I complex; IEA:TreeGrafter.
DR GO; GO:0051751; F:alpha-1,4-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR007704; PIG-M.
DR PANTHER; PTHR12886:SF0; GPI MANNOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR12886; PIG-M MANNOSYLTRANSFERASE; 1.
DR Pfam; PF05007; Mannosyl_trans; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU365064};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU365064};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502,
KW ECO:0000256|RuleBase:RU365064};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365064};
KW Reference proteome {ECO:0000313|Proteomes:UP000055048};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365064};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365064}.
FT TRANSMEM 9..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 118..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 215..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 307..334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 376..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:KRX39481.1"
SQ SEQUENCE 394 AA; 44881 MW; 0AFBB9801722BCB4 CRC64;
MISSAEYRWL LKLLCFSTAV RFLLVTYSQL QDYFFDVKFT DVDYTVMLDA AKLMARGQSP
YERQTYRYTP TFAWLLLPAV RWPLYGKLLF NAFDLLAGLA STVLALSSDS GHSSLGPLLA
LALFNPFTMI ISSRGNAESF VSFLVLFSLL LVEIGGLPAR LCASLFHGFC VHVKIYPIIY
LPSACFKLYQ EKLHQKDDDI DDHVASRPVR FARALGAAAG YAFGVLVGFV APTALAYYKY
GRQYADEALL YHLRRTDYKH NFSPFFLPLY LNADSSTNII AWISYAAFVP QALIVLFLAL
KFARQLPICW FISTLAFVAH NKVCTSQYFV WYLAFLPTVW SGFDCDRGRP VRLLLWWTAG
QALWLLPAYC LEFRGFNFFL PVWIASVLFF LINV
//
