ID A0A0V1I0D8_9BILA Unreviewed; 401 AA.
AC A0A0V1I0D8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-NOV-2024, entry version 20.
DE RecName: Full=GPI mannosyltransferase 1 {ECO:0000256|ARBA:ARBA00013797, ECO:0000256|RuleBase:RU365064};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU365064};
DE AltName: Full=GPI mannosyltransferase I {ECO:0000256|RuleBase:RU365064};
GN Name=pigm {ECO:0000313|EMBL:KRZ15381.1};
GN ORFNames=T11_13918 {ECO:0000313|EMBL:KRZ15381.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ15381.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ15381.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ15381.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-
CC acyl-PI during GPI precursor assembly. {ECO:0000256|ARBA:ARBA00025668,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU365064}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- SIMILARITY: Belongs to the PIGM family. {ECO:0000256|ARBA:ARBA00011071,
CC ECO:0000256|RuleBase:RU365064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ15381.1}.
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DR EMBL; JYDP01000018; KRZ15380.1; -; Genomic_DNA.
DR EMBL; JYDP01000018; KRZ15381.1; -; Genomic_DNA.
DR EMBL; JYDP01000018; KRZ15382.1; -; Genomic_DNA.
DR EMBL; JYDP01000018; KRZ15383.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1I0D8; -.
DR STRING; 268475.A0A0V1I0D8; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990529; C:glycosylphosphatidylinositol-mannosyltransferase I complex; IEA:TreeGrafter.
DR GO; GO:0051751; F:alpha-1,4-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR007704; PIG-M.
DR PANTHER; PTHR12886:SF0; GPI MANNOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR12886; PIG-M MANNOSYLTRANSFERASE; 1.
DR Pfam; PF05007; Mannosyl_trans; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU365064};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU365064};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502,
KW ECO:0000256|RuleBase:RU365064};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365064};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365064};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365064};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365064}.
FT TRANSMEM 88..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 165..189
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 303..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365064"
SQ SEQUENCE 401 AA; 45941 MW; 1AC71330A4B9C164 CRC64;
MISSAEYRWL LKLLCFSTAV RFLLVTYSQL QDYFFDVRFT DVDYTVMLDA AKLMAHGQSP
YERQTYRYTP TFAWLLLPAV RWPLYGKLLF NAFDLLAGLA SIMLALWSNW GPSPLGVLFS
LALLNPFTMI ISSRGNAESL VSFLVLFSLL LVEVGGPLAR LCGSLLHGFC VHVKIYPIIY
LPSACLKLYQ EKLYQKDDEA RLPVRFARAL VAAAGYAFGV LVGFAVPTAL AYHNYGRQYA
DEALLYHLRR TDYKHNFSPF FLPLYLNADD DNTNITAWIS YAAFVPQALI VLFLALKFAR
QLPICWFIST LAFVAHNKVC TSQYFVWYLA FLPVVWSGFD CDRGRPVQLL LWWTAGQALW
LLPAYCLEFR GFNFFLPVWI ASVLFFLINV HIIRRAVVSF R
//
