ID A0A0V1I946_9BILA Unreviewed; 1632 AA.
AC A0A0V1I946;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 02-APR-2025, entry version 31.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:KRZ19338.1};
GN Name=Apaf1 {ECO:0000313|EMBL:KRZ19338.1};
GN ORFNames=T11_5223 {ECO:0000313|EMBL:KRZ19338.1};
OS Trichinella zimbabwensis.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268475 {ECO:0000313|EMBL:KRZ19338.1, ECO:0000313|Proteomes:UP000055024};
RN [1] {ECO:0000313|EMBL:KRZ19338.1, ECO:0000313|Proteomes:UP000055024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1029 {ECO:0000313|EMBL:KRZ19338.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ19338.1}.
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DR EMBL; JYDP01000001; KRZ19338.1; -; Genomic_DNA.
DR STRING; 268475.A0A0V1I946; -.
DR OrthoDB; 1357022at2759; -.
DR Proteomes; UP000055024; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-ARBA.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50209; CARD; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:KRZ19338.1};
KW Protease {ECO:0000313|EMBL:KRZ19338.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000055024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 93..157
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 821..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..842
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1632 AA; 186135 MW; 61FCEA160BCC3FCC CRC64;
MYCNQISACK TNYNFCMDKK DFPQFARKND NFKIKLNISK EHSLFSRTRL ELSCEKTFSS
GYMGVRYCYG NPINRSWYSC FVVGEEQIFQ IMLSEEQNLK LLNSQHSLLT DLEPKEITAY
LQAAGVFSED DIELISAKVT RRERVAQLLT IYRRKARDLG PLVYALDKTG YRHLKIELVN
SVSEVDRGVV PNSKHSLNIL LINGKVPRKP EVYVERKELK LKLKNALMRI DKEPGWIVLH
GMGGCGKSVL AAAVVRDSEI TGGLFSRVFW ITAGRSCDRI RSFALMQDLY SRMGKEFHRL
DSVEEASSRL IELLLFDYPR TLLILDDVWT ESVVRLFDEL QCRILALTRN ASLFDVANNR
KYFVLMEPSG YTKDEAMQAF ASYLNCSESD LPLEALQIFH ECRGHPLLIS LIGALLKEHN
SRWKFYYGLI HSQKLNNIKK VTHYKYATFN EAALLSLEDL TDDLKELYFE LAIFPLGVKI
STQVLTVYWN KSMYEVEDIM AEFVKRSLLI KSSSDCEAVE TYQIHALLHR VIKMSCHSDL
RKTLHQKLLG HYLKVADNCW GKLPEHEYIF TFLGYHLFRS DKFASFPDVF LDLKFLAKKI
ALCGPASVLN DLIYYRKFIR DSHPTLFDQI ERLIKNNSFQ LATNNGKYLS LIHLSLLNKN
LSELYLEAER ILQESDNGAV IDSFAKPYLK SWCKQSFGKD PNFTFSCNSV KCGVWMSRQK
KIIYIGFDSC LGVCCTTTGL QLYRVVLNHV PNYLSFSEND CTLFVAYGNF VGVFELDDHL
KRSTEQDETA SGMDELDCQR TPSPILNHLC NGLSFFRAND QQEQKHPDQQ QQQQQQQQQQ
QQKVDENIWG PKLLQAHEFE VDNCGVELRF CLPARHFPWV LCCDVEGSAK ILETAQGRVS
GGFDQQQHND RSTTHITSCG SNGDDSLLAI GRADGVVELW NPADFRLQCR FAGHHNGPVL
FCAFTGRFTS VECIFSACER RILLWKFDHS RDHHDDHNND HHQSNSVELL EKIQPDQKHI
RIVCVALSPT ENLLAASFTD FSVLIWNLEN KLSTHLVGQC RILKQLYFSE KGKDLLAIRE
DNAVLIFNEI RKSNISLPEI NLIDFVEIKS GLLLASVQDY TLQVSIITDA IATVIETRRL
FDRVSCLKWS PSEYVLMVAF ENGSIQSCRF DGNSLSELKK EFKTPQAPCC LSFSTVSDRL
AVGCKEGCVA IQDAQFHCHG TAFFESAVTK CIFLDRHQHV NQLLICLQDG SFEILNIDSF
IVEAVLGLPV CMIVDFDVNF NCTYLATCWS GKQVKVWNLD NFDPIFEENN FNNSLCKCKL
SKSGNLLAVC ESRGMVNLFK LPDGDLVQKI YAHSSDIYDL VFYDDDNVLI TLSSELKWWN
LKMRSQMRHC LLSTDSARTL NIFPGHNLLV TVDHLQGYHV MQIVSTNNSV PAGRLNVLHN
GCEILKQMFF LLQINLGRLK KKIRDDMSRN LFICFCTLIL LITAVEKFAN ASPSTMQNAQ
LFDSLPAELQ AILVTDDFGM ESISKLPKES INADSFSAFS TIFSEIPDDQ SPTDHSDESI
PLDSAETLLR HVFDLYPQDD EQTPSTEEMD TTKTEDPEKV SSEVKGKKSV AGRLASIFNI
ATQLYTNSHY FV
//
