ID A0A0V1L7C8_9BILA Unreviewed; 808 AA.
AC A0A0V1L7C8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 02-APR-2025, entry version 30.
DE SubName: Full=Rho GTPase-activating protein 10 {ECO:0000313|EMBL:KRZ55180.1};
GN Name=ARHGAP10 {ECO:0000313|EMBL:KRZ55180.1};
GN ORFNames=T02_7816 {ECO:0000313|EMBL:KRZ55180.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ55180.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ55180.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ55180.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ55180.1}.
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DR EMBL; JYDW01000121; KRZ55180.1; -; Genomic_DNA.
DR OrthoDB; 3183924at2759; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF1; RHO GTPASE-ACTIVATING PROTEIN GRAF; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 270..377
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 398..592
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 749..808
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 654..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..666
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 92459 MW; 3D8E02AC87E62F74 CRC64;
MVLKPLEFAD CVTDSPWFRA NLREHELALE RSYKSIKLLE SQSKELISAG QKLQTAQRNF
AKTLQELKLE TIGTTETEDE RIIANSLKEY SKLILQLEDQ RSHILQETEK NFIGPFRKFR
IECIGNAIQH ERKKYEKSSY KFYQTLEKHL HLSTNKRNDF KEADTALEAE QRQFYRASLD
YVCVLQSVQE RMKFEFVENL SSFLYSLLTF YHVGHVIHED FKPYLDHVKY RVQKAKESYY
ATERETEEFR KKMLRLNSMS HPMEMCAGRV AIKQGYLYLC EKKNLVTSWT KYYCVYQKET
RMFAIVPVTQ TLIKDIKEAF CQSISFKLKS CIRRASDTID KRFCFDIISD NDDVLTFQAL
SDEDRRCWLN ALDGKEPFYX XXXXFYSPTS GPCKPMQTSL DNNSYKFVAA LLERIEQNFI
NEQGLYRNCG INSKVQRLLQ TALTTNSGNN NDFTTTTTTT DSNDFSEWDA KTMTSAVKTF
LRSLPEPLMT YALHGQFLSA SKLDSAKERV EHIHYYVHQL PNENFRMLKL LMHHLKRVAE
CASQNLMTAC NLAVCFGPCV LRAEEETVAA IMDIKFYNLV VEVLIDNCDQ IFEGEPKTFI
ASPPSKPPHS CTRRSFDCCT GTFSPKSILK TSENADTKIP ADQTNDDVLS HDGVRVSSSS
VSSSVSNGEE NIDESRTGSI GEFLDQLENV SSFANSRGSA SRTCVKYPRP YTSSKRRLFL
NPKLTIPNKT PPNRPHSPVS RAVSSSGLQA SNRVRTLYEC VADCRCQLSF MPGQILTNVS
KSKEPGWLVG TLNGKPGLVP ENFVEPLP
//
