ID A0A0V1MKP4_9BILA Unreviewed; 1636 AA.
AC A0A0V1MKP4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 28-JAN-2026, entry version 31.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|EMBL:KRZ72424.1};
GN Name=Megf6 {ECO:0000313|EMBL:KRZ72424.1};
GN ORFNames=T10_3201 {ECO:0000313|EMBL:KRZ72424.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ72424.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ72424.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ72424.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ72424.1}.
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DR EMBL; JYDO01000079; KRZ72424.1; -; Genomic_DNA.
DR EMBL; JYDO01000079; KRZ72427.1; -; Genomic_DNA.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR FunFam; 2.10.25.10:FF:000005; Fibrillin 2; 1.
DR FunFam; 2.170.300.10:FF:000002; Multiple epidermal growth factor-like domains 10; 4.
DR FunFam; 2.10.25.10:FF:000037; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.170.300.10:FF:000041; Tyrosine protein kinase receptor tie-1, putative; 4.
DR FunFam; 2.10.25.10:FF:000119; vitamin K-dependent protein S; 1.
DR FunFam; 2.10.25.10:FF:000240; Vitamin K-dependent protein S; 2.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 8.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR052108; MEGF/SIB.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF141; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00053; EGF_laminin; 4.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF12661; hEGF; 8.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 9.
DR SMART; SM00180; EGF_Lam; 23.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS00022; EGF_1; 17.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 65..146
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 145..181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 224..264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 433..473
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 622..652
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 885..915
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1060..1095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1103..1138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1146..1181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1189..1224
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1318..1353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1366..1396
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1404..1439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1490..1525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 642..651
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 905..914
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1085..1094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1128..1137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1171..1180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1214..1223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1343..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1386..1395
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1429..1438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1515..1524
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1636 AA; 177555 MW; 6071A10CB2735690 CRC64;
MFYKRFGQAT TIQQRSLLTV LDLSSLITSG LMMHHRLVIV LFFLFSLLTT SWSVELEVEE
LKPDMKNVCP HEEVEVVTIQ EPCIQAYTRY VRRWKPNCDH QKRWCVISEP KTIYYRTVKT
KQRKERHVRY KCCYGWLPVT GEGCTKPNCT TDLCYNGGSC SSEVAAKLCD CPPGFQGSRC
QYDINECLVD NGGCHHDCSN TIGTFYCRCW PGFQLNSDGK TCVDVNECEI VNGGCEYRCV
NTNGGYRCEC PPNKQLHPDG RHCINENSCE LNNGGCSQLC QEEGGKFLRC RCHSGYKLAD
DKRTCYAIDP CQEDGAKCQH HCVNVNGRAV CQCYSGYRLA YDKRSCTDVN ECELHHRGGC
EQLCVNIPGS FECQCHEGYR LASDRKHCIK LQANCEVNNG GCEHHCTASV DGGVQCNCKH
GFRLADDGKH CVDIDECVNN NAGCDHQCHN QPGSYYCACR PGFHLSIDQH SCEDINECLT
NNGNCQQLCT NVPGSYRCEC FLGYSLDGDK KSCNALYLVR SLKSNESSDP FQLNLFNNKT
EYHLELPQSS AAVHHSHLYN YGLNQQECPI GKFGFKCEYS CDDCKNGGRC NRKQSGCDCR
AGWIGIICNE SCPEGFWGIG CSNVCSCSNG GLCNPITGEC RCLAGYSGES CEVGCPAGYY
GPRCDLPCRM QCPNNICDRT YGYCPCSPGF FGKKCEQTCP PFTYGRNCRH LCKCHRENSV
GCNEQTGECY CKDGFYGPYC KATCPLGYYG PSCRKQCACE VSVGCDPVSG MCEPKCKPGF
TGPDCKQPCS PNRFGVNCAS VCQCPKEQKC HPASGACTCP AGYTGPKCSQ KCPPNRYGPM
CMYECVCKNG ASCDPETGRC QCTAGFYGTA CTEKCPPGRF GRDCMELCSC MNGATCDPVN
GSCACLAGWQ GELCDRVCDA NTFGANCAQS CNCTGDVKCD PVSGDCICPP GLQGERCDQP
CPSGSYGAGC MGVCACKNGA TCDAVSGRCL CASGWRGWHC DRPCPDGFYG KQCAQICDCG
FGSQEGNGAL SRCDHVTGEC LCPSGWTGPD CRTPCPPNRW GNGCTEKCQC ENGGSCDPLT
GLCSCPPGWI GKACDQECPA GLHGINCAQH CHCLNNATCD SRTGKCLCSP GWMGAACEFR
CPFGYFGPSC NGVCQCQAGA ACDHVTGECR CLPGWSGERC DKKCPDGKYG INCSEVCQCE
HGASCHHITG HCLCTPGWRG RRCHRPCIKG YYGRNCAQRC NCPKQNNCDH ITGQCSCPAG
YTGPTCSHLC PEGKFGQDCH SRCSCSANAN CDPVTGDCIC KPGFSGPGCN EGCVQGKFGF
DCKENCTCEN GGICDSVFGK CTCPSGFIGT MCELPCPSNR HGINCIEECP CENGGTCSRT
TGQCVCPPGF TGINCKLVCP ETKYGAGCTE KCRCKNGGFC NPVDGTCKCT LGWTGPSCEQ
ECPKGRYGAG CALECRCHNN AHCDRITGCC DCPDGFYGSM CEFKCPEGMY GWYCSKFCNC
LNGAACDPTT GQCLCPPGFH GDKCESTCPI GSYGVNCRLK CDCGDYDCDS TTGQCICPLG
FTGPRCQDVC RSGRYGFNCE QSCKCYNGAR CNMFTGQCEC AAGWLGATCQ REDYSHNVLP
SRGDVPNHVN RGYYRR
//
