ID A0A0X1RZ88_9BACL Unreviewed; 340 AA.
AC A0A0X1RZ88;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 18-JUN-2025, entry version 42.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081,
GN ECO:0000313|EMBL:AMA63794.1};
GN ORFNames=ASO14_1106 {ECO:0000313|EMBL:AMA63794.1};
OS Kurthia sp. 11kri321.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Caryophanaceae;
OC Kurthia.
OX NCBI_TaxID=1750719 {ECO:0000313|EMBL:AMA63794.1, ECO:0000313|Proteomes:UP000058129};
RN [1] {ECO:0000313|EMBL:AMA63794.1, ECO:0000313|Proteomes:UP000058129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11kri321 {ECO:0000313|EMBL:AMA63794.1,
RC ECO:0000313|Proteomes:UP000058129};
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|ARBA:ARBA00055319, ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP013217; AMA63794.1; -; Genomic_DNA.
DR RefSeq; WP_068452559.1; NZ_CP013217.1.
DR AlphaFoldDB; A0A0X1RZ88; -.
DR STRING; 1750719.ASO14_1106; -.
DR KEGG; kur:ASO14_1106; -.
DR PATRIC; fig|1750719.3.peg.1046; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000058129; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR FunFam; 1.10.10.10:FF:000049; Heat-inducible transcription repressor HrcA; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.390.60; Heat-inducible transcription repressor hrca homolog, domain 3; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR006199; LexA_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF01726; LexA_DNA_bind; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000058129};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 2..61
FT /note="LexA repressor DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF01726"
FT DOMAIN 104..322
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 340 AA; 38678 MW; 802A16954ABB29CD CRC64;
MLTDRQLQIL KVIVDDFISS GQPIGSRQIS KREEISFSSS TIRNEMADLE ELGYLEKTHT
SSGRIPSEKG YRFYVDHLLK PQVITNHDMK VLRSVFSENA YETEQVIRKS ATILSDLTNY
TSIILGPDVQ LHKVKRFSIV PLSAKNAVAI IVTDNGHVEN RVVDLPEGLH PSDFEKMVNI
LNERLVGIPI VQIPYYLERE VSNIIRQHVG AYNGLLKSIF TGIEQQSDSK IYYGGKTNML
NQPEFHDLDK IRMLMEMMET QSQIQALLHR DSPGIQIRIG SENELNAVED CSIITATYST
NEEQVGSIAI IGPKRMDYQR VITLLDHMSG DLSKLMRREW
//
