ID A0A103YDS1_CYNCS Unreviewed; 630 AA.
AC A0A103YDS1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 08-OCT-2025, entry version 32.
DE RecName: Full=Reticulon-like protein {ECO:0000256|RuleBase:RU363132};
DE Flags: Fragment;
GN ORFNames=Ccrd_014395 {ECO:0000313|EMBL:KVI07221.1};
OS Cynara cardunculus var. scolymus (Globe artichoke) (Cynara scolymus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; campanulids; Asterales; Asteraceae; Carduoideae; Cardueae;
OC Carduinae; Cynara.
OX NCBI_TaxID=59895 {ECO:0000313|EMBL:KVI07221.1, ECO:0000313|Proteomes:UP000243975};
RN [1] {ECO:0000313|EMBL:KVI07221.1, ECO:0000313|Proteomes:UP000243975}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2C {ECO:0000313|EMBL:KVI07221.1};
RX PubMed=26786968; DOI=10.1038/srep19427;
RA Scaglione D., Reyes-Chin-Wo S., Acquadro A., Froenicke L., Portis E.,
RA Beitel C., Tirone M., Mauro R., Lo Monaco A., Mauromicale G., Faccioli P.,
RA Cattivelli L., Rieseberg L., Michelmore R., Lanteri S.;
RT "The genome sequence of the outbreeding globe artichoke constructed de novo
RT incorporating a phase-aware low-pass sequencing strategy of F1 progeny.";
RL Sci. Rep. 6:19427-19427(2016).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU363132}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU363132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KVI07221.1}.
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DR EMBL; LEKV01001509; KVI07221.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A103YDS1; -.
DR STRING; 59895.A0A103YDS1; -.
DR Gramene; KVI07221; KVI07221; Ccrd_014395.
DR OMA; LTYGECD; -.
DR Proteomes; UP000243975; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR050425; NAD(P)_dehydrat-like.
DR InterPro; IPR003388; Reticulon.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR PANTHER; PTHR10366:SF564; STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF02453; Reticulon; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU363132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363132};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000243975};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363132}.
FT TRANSMEM 458..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT TRANSMEM 554..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363132"
FT DOMAIN 447..605
FT /note="Reticulon"
FT /evidence="ECO:0000259|PROSITE:PS50845"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KVI07221.1"
SQ SEQUENCE 630 AA; 70485 MW; F3C02D1020E7580A CRC64;
ALKHKIGLCP VSSIVLCRFR RRSNLEENHE AQIEGLSFRP PFLAAKSRPI SKLQVPRFCT
VIIFFNLDIC FFLSTYEIYS VRIADLAPDI KLETHEEKGN LGQALRLGRA QYVSMDLCDK
SQVNKACEGA EVVFHMAAPD SSINNYKLHY AVNVQGTKNV IDACTKLNVK RLIYTSSPSV
VFDGVHGIYN GDESLPYAAK HNDSYSETKA EGEALVIKAN GINGLLTCCI RPSSIFGPGD
KLLVPSLVAA ARAGKSKFII GDGTNMYDFT YVENVAHAHV CAERALASDG SASKRAAGEV
LAWHVPVDAR IYYFKLFFQA YFVTNMEPIK FWEFMSLILV GLGYERPRIK IPAAVMMPIA
HLVERTYNIL APYGMKVPQL TPSRIRLLTC NRTFNSGKAN DRLGYIPIVP LQGLKRTIES
YPDLRAELLP RKEGPSKAAV YLGNGIVADI LLWRDTKLTF TGMLALIVFY VSFVLPGSTM
ITAVSKVLMW ASILIFIHGK LPNHLMGYSV EKIPESKFQC SEEMSRRTAL SVASSWNCAV
NNLKSISSGH DWTLFFKMAI SLFIVSCIGS MSLQSFFLKV VPFSFVVFYI YDQYEDEVDR
IVQTVIPIER LSNPDFLRLL NPFKPLDKQH
//
