ID A0A133VF06_9EURY Unreviewed; 149 AA.
AC A0A133VF06;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 05-FEB-2025, entry version 27.
DE RecName: Full=Transcription elongation factor Spt5 {ECO:0000256|HAMAP-Rule:MF_00950, ECO:0000256|NCBIfam:TIGR00405};
GN Name=nusG {ECO:0000313|EMBL:KXB05023.1};
GN Synonyms=spt5 {ECO:0000256|HAMAP-Rule:MF_00950};
GN ORFNames=AKJ49_01485 {ECO:0000313|EMBL:KXB05023.1};
OS candidate division MSBL1 archaeon SCGC-AAA382A03.
OC Archaea; Methanobacteriati; Methanobacteriota; candidate division MSBL1.
OX NCBI_TaxID=1698278 {ECO:0000313|EMBL:KXB05023.1, ECO:0000313|Proteomes:UP000070549};
RN [1] {ECO:0000313|EMBL:KXB05023.1, ECO:0000313|Proteomes:UP000070549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA382A03 {ECO:0000313|EMBL:KXB05023.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- FUNCTION: Stimulates transcription elongation. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
CC -!- SUBUNIT: Heterodimer composed of Spt4 and Spt5. Interacts with RNA
CC polymerase (RNAP). {ECO:0000256|HAMAP-Rule:MF_00950}.
CC -!- SIMILARITY: Belongs to the SPT5 family.
CC {ECO:0000256|ARBA:ARBA00006956}.
CC -!- SIMILARITY: Belongs to the archaeal Spt5 family. {ECO:0000256|HAMAP-
CC Rule:MF_00950}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB05023.1}.
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DR EMBL; LHYC01000037; KXB05023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133VF06; -.
DR PATRIC; fig|1698278.3.peg.286; -.
DR Proteomes; UP000070549; Unassembled WGS sequence.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09887; NGN_Arch; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR HAMAP; MF_00950; Spt5_arch; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR011590; Spt5_arc.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR NCBIfam; TIGR00405; KOW_elon_Spt5; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR SMART; SM00739; KOW; 1.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000070549};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00950};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00950}.
FT DOMAIN 2..82
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 87..114
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
SQ SEQUENCE 149 AA; 16813 MW; 7FC10FA974FEA9A5 CRC64;
MFAIRTTIGQ EKNTAEMINS RIESRDLPIK ALLVPQDIRG YIFIEADGKS AVERARSGVK
HAKGLIERKV SLKEIEELME PKPTISGMEK GDIVELTGGP FKGERGRIIR IEDTKEEATI
ELFEATVPIP VTVRGDRVRV VERKREEEE
//
