ID A0A140L341_9FIRM Unreviewed; 639 AA.
AC A0A140L341;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:KXG74966.1};
GN ORFNames=AN618_20900 {ECO:0000313|EMBL:KXG74966.1};
OS Fervidicola ferrireducens.
OC Bacteria; Bacillati; Bacillota; Clostridia; Thermosediminibacterales;
OC Thermosediminibacteraceae; Fervidicola.
OX NCBI_TaxID=520764 {ECO:0000313|EMBL:KXG74966.1, ECO:0000313|Proteomes:UP000070427};
RN [1] {ECO:0000313|EMBL:KXG74966.1, ECO:0000313|Proteomes:UP000070427}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y170 {ECO:0000313|EMBL:KXG74966.1,
RC ECO:0000313|Proteomes:UP000070427};
RA Patel B.K.;
RT "Draft genome sequnece of Fervidicola ferrireducens strain Y170.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXG74966.1}.
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DR EMBL; LOED01000035; KXG74966.1; -; Genomic_DNA.
DR RefSeq; WP_066354724.1; NZ_LOED01000035.1.
DR AlphaFoldDB; A0A140L341; -.
DR FunCoup; A0A140L341; 423.
DR STRING; 520764.AN618_20900; -.
DR PATRIC; fig|520764.3.peg.2235; -.
DR InParanoid; A0A140L341; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000070427; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:KXG74966.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000070427}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 639 AA; 71313 MW; 84B7194A4D309395 CRC64;
MSGVIIGTAG HIDHGKTTLI KAMTGIDTDR LKEEKERGIT IDLGFAHLLL PSGRKVGIVD
VPGHEKFVKN MLAGAGGIDL VLLVIAADEG VMPQTREHLN ILQLLNIKKG IVVVTKKDLV
DEEWLEMVKE DIQKELKGTF LENSPMIFVS AVTGEGIKEL VELIDRMTAE SYERDLDSPF
RLPVDRAFSI PGIGTVVTGS LICGRISVGE TVEIFPKGLL SKVRSIEVHG ESKESAYAGQ
RTAVNLSDVK PEDISRGDVV SKVKAMMPVN RAAVWFKLLK DSPKALKNRE RVRFHAGTGE
VMARISLVEG DELLPGMETF AIVDFEEPVA VVYGDYYVVR SYSPVYTIGG GQVLFVNPPR
LKRALKDKAL EALKKAKEGG LEDFIVGFVS VFGSPNIPVK DLVPYTGKSF ERLMEAAKSL
SEKGKVLVLH VGTEDEVFDI KFYEEKRARA KEILENYHQK FPLSEGMAKE ELRSRLDLAG
KVFEALLDMW AKEGIVESRG KTVQLKGFTV RMDEKQKKIA DMLLREFKEK GWAPPSVEEL
QALFGVEAGA VKEVLNWLVS KGDIVKIGEE LYMAREWVER ARELLREFFR ENGELTVAQF
RDMLGTTRKY ALPLLEYMDG IKATRRLKDT RVAGIRLYE
//
