ID A0A146FW76_ASPKA Unreviewed; 505 AA.
AC A0A146FW76;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE SubName: Full=Sphinganine kinase lcb4 {ECO:0000313|EMBL:BCR97376.1};
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:GAT29409.1};
GN Name=LCB4 {ECO:0000313|EMBL:BCR97376.1};
GN ORFNames=AKAW2_30695A {ECO:0000313|EMBL:BCR97376.1}, RIB2604_02902820
GN {ECO:0000313|EMBL:GAT29409.1};
OS Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1069201 {ECO:0000313|EMBL:GAT29409.1, ECO:0000313|Proteomes:UP000075230};
RN [1] {ECO:0000313|EMBL:GAT29409.1, ECO:0000313|Proteomes:UP000075230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIB 2604 {ECO:0000313|EMBL:GAT29409.1,
RC ECO:0000313|Proteomes:UP000075230};
RX PubMed=27651094;
RA Yamada O., Machida M., Hosoyama A., Goto M., Takahashi T., Futagami T.,
RA Yamagata Y., Takeuchi M., Kobayashi T., Koike H., Abe K., Asai K.,
RA Arita M., Fujita N., Fukuda K., Higa K., Horikawa H., Ishikawa T.,
RA Jinno K., Kato Y., Kirimura K., Mizutani O., Nakasone K., Sano M.,
RA Shiraishi Y., Tsukahara M., Gomi K.;
RT "Genome sequence of Aspergillus luchuensis NBRC 4314.";
RL DNA Res. 23:507-515(2016).
RN [2] {ECO:0000313|Proteomes:UP000075230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIB 2604 {ECO:0000313|Proteomes:UP000075230};
RA Yamada O.;
RT "Genome sequencing of Aspergillus luchuensis NBRC 4314.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BCR97376.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:BCR97376.1};
RG Aspergillus luchuensis mut. kawachii IFO 4304 genome sequencing consortium;
RA Kazuki M., Futagami T.;
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:BCR97376.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:BCR97376.1};
RA Mori K., Kadooka C., Goto M., Futagami T.;
RT "Aspergillus luchuensis mut. kawachii IFO 4304 genome sequence.";
RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AP024427; BCR97376.1; -; Genomic_DNA.
DR EMBL; BCWF01000028; GAT29409.1; -; Genomic_DNA.
DR RefSeq; XP_041541142.1; XM_041687238.1.
DR AlphaFoldDB; A0A146FW76; -.
DR GeneID; 64958701; -.
DR KEGG; aluc:AKAW2_30695A; -.
DR VEuPathDB; FungiDB:ASPFODRAFT_130130; -.
DR OrthoDB; 3853857at2759; -.
DR Proteomes; UP000075230; Unassembled WGS sequence.
DR Proteomes; UP000661280; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:GAT29409.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000661280};
KW Transferase {ECO:0000313|EMBL:GAT29409.1}.
FT DOMAIN 136..275
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 343..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 505 AA; 54685 MW; FE9FAE6A11E6FDDA CRC64;
MTTSNGPPRP SFNNADHPET RDQLLEHDAT LIVSNSVSLT IGGDSLLIVD ERSMRKAERG
CCGIASKTAK PTHSIALYNV LDADLSPEGL TITYAEPASK EDVSVSALRY PFAPEEKAAV
ESWTNKLLSV AYGTAKRYKR LKVLVNPFGG QGHAVKLYTS YAAPVFAAAR CQVDVQETTH
GGHAVEIVEQ LDINAYDAII CCSGDGLPYE VFNGLAKKPN AGEALAKVAV AMVPCGSGNA
MAWNLCGTGS VSVAALAIVK GIRTPMDLVS ITQGKTRTLS FLSQSFGIIA ESDLGTDDIR
WMGAHRFTYG FLKRIMRRAV YPCDLAIKTV MDDKQAIKDH YSAYAQSQPP SRPDEDTAEQ
PTGLPELAYG TVLDELPKDW EVIPAENLGN FYAGKMAIVS KDTNFFPASL PNDGLMDIVT
IDGTLSRLTT LKMMTAIPEG EFFDMPDVKV RKALAYRLVP HEKKGYISID GESIPFEAFQ
VEIHKGLGTV LSRSGHLYEA EGPKP
//
