ID A0A151I9B3_9HYME Unreviewed; 733 AA.
AC A0A151I9B3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 18-JUN-2025, entry version 27.
DE RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN ORFNames=ALC62_13991 {ECO:0000313|EMBL:KYM95364.1};
OS Cyphomyrmex costatus.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Cyphomyrmex.
OX NCBI_TaxID=456900 {ECO:0000313|EMBL:KYM95364.1, ECO:0000313|Proteomes:UP000078542};
RN [1] {ECO:0000313|EMBL:KYM95364.1, ECO:0000313|Proteomes:UP000078542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS0001 {ECO:0000313|EMBL:KYM95364.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYM95364.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Cyphomyrmex costatus WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The
CC APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked
CC branched ubiquitin chains on target proteins.
CC {ECO:0000256|ARBA:ARBA00045696}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the APC5 family.
CC {ECO:0000256|ARBA:ARBA00007450}.
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DR EMBL; KQ978296; KYM95364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151I9B3; -.
DR STRING; 456900.A0A151I9B3; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000078542; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:TreeGrafter.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IEA:TreeGrafter.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IEA:TreeGrafter.
DR CDD; cd16270; Apc5_N; 1.
DR InterPro; IPR037679; Apc5.
DR InterPro; IPR026000; Apc5_dom.
DR InterPro; IPR048968; Apc5_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR Pfam; PF12862; ANAPC5; 1.
DR Pfam; PF21371; Apc5_N; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000078542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 21..158
FT /note="Anaphase-promoting complex subunit 5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21371"
FT DOMAIN 236..332
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000259|Pfam:PF12862"
SQ SEQUENCE 733 AA; 82546 MW; 0C86E7D2F6BD24CC CRC64;
MSKEFVTVDG NVRKIQKETL TPYKVATVIL IKEYCNDTTK TIMERRNFCL ASLKLIQSAD
MEFDALLNML YEPEYTLNRF AVRLEINLEA IHEKGIDQLL DLFDNLRRLM ESKDHALSLP
ALSRNSVLGL YVRRMLIFFE KLAFDQVVAL YNDMEKYVVK KIDSLENSDI AISKQEDFFG
PDNKAKTIWG GRQAELLVAQ QAHALQTDEH KALPPVKLQA LVQDLLKSNP YNADAHYLSY
LNCIRVNDFC GAVDSLYHCF DRLAPLENQS TPEDRSRTFR YAALNLAVLH AQFNHKEVAL
YALKEAIKLA QETGDNVCLQ LAHSWMSYLI SKENKGSLIE RSIGKASLLG ITHTTGLSLI
SHAHSYALEA KNPPLVFEIL MKSDMLNCQH SMSDLMSINF AEKSALWAYY GKMEMASLCG
QLLLLHNTGD KKQHMFNGPS TCQAIVTVAN MLIEFGEYVL ADVVLAHAKE RFPNSPCNKI
WMLSEQLHIL TQLLRQEKWG EAEAVARNIS SLDQLESKLK LAEVCLAKGD YPKGLEYIGA
IKKHPHMTPP YVIRALLLSS QITCASSLSD NGTAVATNCI MRLCSALKLA EQNHLSYYKA
LVKMHLANIQ LLMGLPVLAL NLVEEAIPTV LGHGGCYDQG KGFMLYSKCL IASAPENPFE
ARKNMILSGI KTLSKAQELF TKVNAIAKVK STLHLQAVFY NEIDLLPERN QCAFEFRQMD
EQYPTTPTNL ILY
//
