ID A0A179F951_METCM Unreviewed; 525 AA.
AC A0A179F951;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Purple acid phosphatase {ECO:0000256|RuleBase:RU361203};
DE EC=3.1.3.2 {ECO:0000256|RuleBase:RU361203};
GN ORFNames=VFPPC_07269 {ECO:0000313|EMBL:OAQ62045.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ62045.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ62045.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ62045.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate;
CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;
CC Evidence={ECO:0000256|RuleBase:RU361203};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. Purple
CC acid phosphatase family. {ECO:0000256|RuleBase:RU361203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ62045.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSBJ02000007; OAQ62045.1; -; Genomic_DNA.
DR RefSeq; XP_018139749.1; XM_018286158.1.
DR AlphaFoldDB; A0A179F951; -.
DR STRING; 1380566.A0A179F951; -.
DR GeneID; 28850152; -.
DR KEGG; pchm:VFPPC_07269; -.
DR OrthoDB; 45007at2759; -.
DR Proteomes; UP000078397; Unassembled WGS sequence.
DR GO; GO:0003993; F:acid phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd00839; MPP_PAPs; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 2.60.40.380; Purple acid phosphatase-like, N-terminal; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR041792; MPP_PAP.
DR InterPro; IPR039331; PAPs-like.
DR InterPro; IPR025733; PAPs_C.
DR InterPro; IPR015914; PAPs_N.
DR InterPro; IPR008963; Purple_acid_Pase-like_N.
DR PANTHER; PTHR22953; ACID PHOSPHATASE RELATED; 1.
DR PANTHER; PTHR22953:SF153; PURPLE ACID PHOSPHATASE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF14008; Metallophos_C; 1.
DR Pfam; PF16656; Pur_ac_phosph_N; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF49363; Purple acid phosphatase, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361203};
KW Reference proteome {ECO:0000313|Proteomes:UP000078397};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361203}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT CHAIN 25..525
FT /note="Purple acid phosphatase"
FT /evidence="ECO:0000256|RuleBase:RU361203"
FT /id="PRO_5007950156"
FT DOMAIN 38..121
FT /note="Purple acid phosphatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16656"
FT DOMAIN 178..402
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 424..485
FT /note="Purple acid phosphatase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14008"
SQ SEQUENCE 525 AA; 57645 MW; C8022443E1A59363 CRC64;
MALLHRAAVA LVLLVFATSD CVVAHNRYPP KPVDLTTPVQ QHIAIHGPNE VSVAWGTYKR
LSEPCVEFGT SNDTLTRRAC SKTSVTYPTS RTWFNSVILD GLTPATTYYY KIVSTNSSVD
QFMSPRIAGD TTPFAMNVVI DLGVYGADGY TTDKRDLIPT IEPSLNHSTI GRLATTINDY
EFIIHPGDFA YADKWYENPK NREDGEAAYT SILEQFYQQL APIASRKPYM ASPGNHEAGC
DITRHIEGDC PTGQSNFTDF MNRFGPVAPT AFASSSYNAT AKSKAATAQR LARPPFWYSF
EYGMAHVVMF NTETDFFKAP EGIGGWTGDD SGPFGFPNQQ LDFLEADLAS VDRTVTPWLI
VAAHRPWYTT GGGEVCRPCK QAFEPVFAKY GVDLAIFGHV HNSQRFVPVN DSVADPKGMN
NPTAPMYIVA GGAGNIEGLK HIGKNVSYNA FAYAEDFSFA TIKFKDKQHL QVDFIRSRTG
EVIDTSVLYK EHAQQFTLVD GKPSSSGSRL GAFLAIIVLA FAVAI
//
