ID A0A179U6V7_BLAGS Unreviewed; 495 AA.
AC A0A179U6V7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 28-JAN-2026, entry version 27.
DE SubName: Full=Sphingosine kinase, variant {ECO:0000313|EMBL:OAT03560.1};
GN ORFNames=BDBG_00264 {ECO:0000313|EMBL:OAT03560.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT03560.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
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DR EMBL; GG657448; OAT03560.1; -; Genomic_DNA.
DR RefSeq; XP_031575706.1; XM_031719817.1.
DR AlphaFoldDB; A0A179U6V7; -.
DR GeneID; 8508259; -.
DR VEuPathDB; FungiDB:BDBG_00264; -.
DR OrthoDB; 3853857at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OAT03560.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 126..265
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 495 AA; 54314 MW; F3A2C10B6F60F7B0 CRC64;
MTIGAPVLDA GPSGNKGTQS VVEDVLHPNS DSSATLEVGK TALLTLAADA IIVTESSGTL
TTRSIPYTNI LWAEVSHDYI TIEYAHQVTN TDVALRSVYF PVSLEQKSKA ETWTEKLLDL
AYGKAQRQKR IKVLINPFGG KGRAAKYYYK HVKPIFAAAK CRVDAELTNY RGHAVDIVEK
LDVDAYDVIA TCSGDGIPYE VFNGLAKKPN ASEALRKIAV ANLPCGSGNA MSWNLNGTGS
ASLAALWIVK GLRTPLDLVS ITQGDKRTVS FLSQSFGIVA ESDLGTENIR WMGQARFTYG
FLVRLFGKTV YPCDLAVKVE LDNKEQIKDH YRAGSERKSF EQLRGEESSD CVGLPPLRYG
TVNDPLPEGW TLVPHDKLGN FYAGNMAYMA ADANFFPTAL PNDGCMDLIT INGDISRRTA
LQMLMAVDNG TLFDMPEVNV RKVTAYRIIP RDRKDGYISI DGERVPFEPF QAEVHRGLGT
VLSRSGYRYE TIGLK
//
