ID   A0A182Y9D8_ANOST        Unreviewed;       510 AA.
AC   A0A182Y9D8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   10-JUN-2026, entry version 42.
DE   SubName: Full=E3 ubiquitin-protein ligase {ECO:0000313|EnsemblMetazoa:ASTEI05074-PA};
OS   Anopheles stephensi (Indo-Pakistan malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=30069 {ECO:0000313|EnsemblMetazoa:ASTEI05074-PA, ECO:0000313|Proteomes:UP000076408};
RN   [1] {ECO:0000313|Proteomes:UP000076408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Indian {ECO:0000313|Proteomes:UP000076408};
RX   PubMed=25244985; DOI=10.1186/preaccept-1262842421127991;
RA   Jiang X., Peery A., Hall A.B., Sharma A., Chen X.G., Waterhouse R.M.,
RA   Komissarov A., Riehle M.M., Shouche Y., Sharakhova M.V., Lawson D.,
RA   Pakpour N., Arensburger P., Davidson V.L., Eiglmeier K., Emrich S.,
RA   George P., Kennedy R.C., Mane S.P., Maslen G., Oringanje C., Qi Y.,
RA   Settlage R., Tojo M., Tubio J.M., Unger M.F., Wang B., Vernick K.D.,
RA   Ribeiro J.M., James A.A., Michel K., Riehle M.A., Luckhart S.,
RA   Sharakhov I.V., Tu Z.;
RT   "Genome analysis of a major urban malaria vector mosquito, Anopheles
RT   stephensi.";
RL   Genome Biol. 15:459-459(2014).
RN   [2] {ECO:0000313|EnsemblMetazoa:ASTEI05074-PA}
RP   IDENTIFICATION.
RC   STRAIN=Indian {ECO:0000313|EnsemblMetazoa:ASTEI05074-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A182Y9D8; -.
DR   STRING; 30069.A0A182Y9D8; -.
DR   PaxDb; 30069-A0A182Y9D8; -.
DR   EnsemblMetazoa; ASTEI05074-RA; ASTEI05074-PA; ASTEI05074.
DR   VEuPathDB; VectorBase:ASTE007089; -.
DR   VEuPathDB; VectorBase:ASTEI05074; -.
DR   VEuPathDB; VectorBase:ASTEI20_041590; -.
DR   OMA; QYCYELE; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000076408; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IEA:TreeGrafter.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.210.10; Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR004162; SINA-like_animal.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR013010; Znf_SIAH.
DR   PANTHER; PTHR45877; E3 UBIQUITIN-PROTEIN LIGASE SIAH2; 1.
DR   PANTHER; PTHR45877:SF2; E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED; 1.
DR   Pfam; PF21361; Sina_ZnF; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 1.
DR   PROSITE; PS51081; ZF_SIAH; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076408};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          61..124
FT                   /note="SIAH-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51081"
FT   REGION          275..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..295
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..368
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  56569 MW;  1BF1F276EBD3759B CRC64;
     MENFRCAQCK CFPNGDVWNC TAKEHFYCAP CKESKGITLC ACGAQLQEEQ VSNPIEKLLY
     QAMCPCRYAP NGCTWKFVKS EMEAHVLECR FRPYRCVAHT LNVLKCDWEG VQHQIENHLT
     EGHKELGPMF RFRQSTSLVF KEQISLGGLK VVDAFSKRFL FHFFSDVANR KLSFLMIYFG
     RREEANQYCY ELELRAAPIP SSDAAEPAEK EKATFARSVK FVERCCSDSE DLAALLQQDR
     CITLAHRQVL NYLHEGKLHM AYKVRKVDAV GREKKLSTSS VPGAEAASVS STASTKPKPR
     PPPFVFANKE KVASNSKRSS SASSSASSKS TSSSESVSSS SASQSTTKAS PSPSSLPSRT
     PSSASTATVC SERNSVDALA SAVNRSSLSS INRVTTPLTP FEKPEQCPLL TPSINKHDVP
     PTWVISQTTT SGFAYHTSTE YHRQMYGHEP YRSLHRYPPG ECTTTAAVCQ KYTQPYKEKD
     DRPYLMKHPT NCLYKPQPKW SAGGGGKGGG
//