ID A0A195F964_9HYME Unreviewed; 154 AA.
AC A0A195F964;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 08-OCT-2025, entry version 23.
DE RecName: Full=Iron-sulfur cluster assembly 2 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00073313};
DE AltName: Full=HESB-like domain-containing protein 1 {ECO:0000256|ARBA:ARBA00077082};
GN ORFNames=ALC56_08936 {ECO:0000313|EMBL:KYN37145.1};
OS Trachymyrmex septentrionalis.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=34720 {ECO:0000313|EMBL:KYN37145.1, ECO:0000313|Proteomes:UP000078541};
RN [1] {ECO:0000313|EMBL:KYN37145.1, ECO:0000313|Proteomes:UP000078541}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tsep2-gDNA-1 {ECO:0000313|EMBL:KYN37145.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYN37145.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex septentrionalis WGS genome.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. May be
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000256|ARBA:ARBA00057540}.
CC -!- SUBUNIT: Heterotetramer; forms a dimer of dimers with IBA57. Interacts
CC with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57
CC complex; [2Fe-2S] cluster binding is absolutely required to promote the
CC complex formation. {ECO:0000256|ARBA:ARBA00093471}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family.
CC {ECO:0000256|ARBA:ARBA00006718}.
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DR EMBL; KQ981727; KYN37145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A195F964; -.
DR STRING; 34720.A0A195F964; -.
DR Proteomes; UP000078541; Unassembled WGS sequence.
DR GO; GO:0120510; C:mitochondrial [4Fe-4S] assembly complex; IEA:UniProtKB-ARBA.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:TreeGrafter.
DR GO; GO:0005506; F:iron ion binding; IEA:TreeGrafter.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR FunFam; 2.60.300.12:FF:000006; Iron-sulfur cluster assembly 2 mitochondrial; 1.
DR Gene3D; 2.60.300.12; HesB-like domain; 1.
DR InterPro; IPR016092; ATAP.
DR InterPro; IPR000361; ATAP_core_dom.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR NCBIfam; TIGR00049; iron-sulfur cluster assembly accessory protein; 1.
DR PANTHER; PTHR43011; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43011:SF1; IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; HesB-like domain; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000078541}.
FT DOMAIN 49..146
FT /note="Core"
FT /evidence="ECO:0000259|Pfam:PF01521"
SQ SEQUENCE 154 AA; 17309 MW; AF959D3514A7797D CRC64;
MAKLTHVMWG LSSNFAANRY FSRLLAKNHL ISSRRKNNLT AITYYLNDLI ISDSCVKRLK
EIADDSTCLR IIVEGGGCSG FQYKFDLDPN IQEDDRIFQK DGTKVIIDST SLEYVKGSTI
EFHTELIRSA FRITNNPLAE QGCSCGASFA IKVE
//
