ID A0A1A6A558_9TREE Unreviewed; 879 AA.
AC A0A1A6A558;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=I303_04531 {ECO:0000313|EMBL:OBR85199.1}, I303_104491
GN {ECO:0000313|EMBL:WWC61905.1};
OS Kwoniella dejecticola CBS 10117.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296121 {ECO:0000313|EMBL:OBR85199.1};
RN [1] {ECO:0000313|EMBL:OBR85199.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:OBR85199.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus dejecticola CBS10117.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:WWC61905.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:WWC61905.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:WWC61905.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:WWC61905.1};
RA Coelho M.A., David-Palma M., Shea T., Bowers K., McGinley-Smith S.,
RA Mohammad A.W., Gnirke A., Yurkov A.M., Nowrousian M., Sun S., Cuomo C.A.,
RA Heitman J.;
RT "Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis
RT evolution and contrasting modes of karyotype evolution via chromosome
RT fusion or intercentromeric recombination.";
RL Submitted (FEB-2024) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI894031; OBR85199.1; -; Genomic_DNA.
DR EMBL; CP144534; WWC61905.1; -; Genomic_DNA.
DR RefSeq; XP_018263041.1; XM_018407830.1.
DR AlphaFoldDB; A0A1A6A558; -.
DR STRING; 1296121.A0A1A6A558; -.
DR GeneID; 28968230; -.
DR KEGG; kdj:28968230; -.
DR VEuPathDB; FungiDB:I303_04531; -.
DR OrthoDB; 2563779at2759; -.
DR Proteomes; UP000078595; Chromosome 5.
DR GO; GO:0009888; P:tissue development; IEA:TreeGrafter.
DR CDD; cd00055; EGF_Lam; 1.
DR CDD; cd00064; FU; 3.
DR Gene3D; 2.10.220.10; Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2; 4.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR050440; Laminin/Netrin_ECM.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR PANTHER; PTHR10574:SF434; PROTEIN TAG-53-RELATED; 1.
DR Pfam; PF23106; EGF_Teneurin; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00261; FU; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000078595};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..879
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008342111"
FT TRANSMEM 610..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..187
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 707..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 154..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 158..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 177..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 879 AA; 93891 MW; AB5E058F1E8BBD40 CRC64;
MTIIFSSTIA FALSTTYTWA HQVCSPETCL DGKAASPLLA HDPALSKYLT PGTYMDPSLD
PSSSLLNIIK SSDSSTVSFP SSPIGFSGNE YSKSEDVWDN GNWSMDRWKS LYLPSTWFGV
LENGKVVWGA IPDKGQLPND LTGLKLSKAA SAACDPPCSS HGVCLPSNIT SGGTCQCSIG
WTGASCDQCQ SGYWGSSCSP GPQDCTIWDD GRSGTGACLG TKTSSLSSCN CDHGTCTSTT
QCACSAGWIT NGTVSPSLCN SCAAGFFGTS NGDCSACPLG CDNCTLQQGS NTTATCTSCS
NNLTLSSGSP ATCSTSSGSC ADGTYFDETS STCATCSPAC STCTGPSPSD CLSCASPRVN
LQGSCVFYDA TTGICDSGLS KLEGVYVVNL AKSRCDACPS GCLDCHIPSF TNTKEFESLQ
CSACREGYLL EDGKCVKKCD AGWYLPEGSA AKNGTCQKCD STCSNCVTSS TTCTSCPAPL
FASGGSCRTT CPESTIPLNG TCVPCPVDCA TCSSPSTCST CPPSRPVLSN GKCIEHCPQD
QYFDSTHGCQ ACDWRCSSCS ANDAKSCTSC SDGYKLSKGE CVASACGDGG FASGLGICLS
SLVTRSKKGY FGFFALAVLI VGAGVGAFYL YVRRERRKTR EATKVFGDKL DDRAVQDNLR
KLRLERVLGL ERILISDTTD RGRGYEEKKN KRFRELLLPS RRRRTDVEND IEMKSTNFAP
DRTDRSTYGY GAPPPPYAPS DLSPSPQDTK HPRNHNQNKN QTPLTARRDS LDSIPTPVLP
TFNSSPIQRS FPDRPKSERK QSNGQSSTTI HSMSSPVSPE YASTSLMPPL RPGMSRQNTQ
EREKERKINR DRDATGEFEM ERRLRDLWPN LRRKDEGWI
//
