ID A0A1A6A8S1_9TREE Unreviewed; 889 AA.
AC A0A1A6A8S1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 02-APR-2025, entry version 34.
DE SubName: Full=E3 ubiquitin-protein ligase RNF216 {ECO:0000313|EMBL:OBR86456.1};
GN ORFNames=I303_02463 {ECO:0000313|EMBL:OBR86456.1}, I303_102448
GN {ECO:0000313|EMBL:WWC59886.1};
OS Kwoniella dejecticola CBS 10117.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Kwoniella.
OX NCBI_TaxID=1296121 {ECO:0000313|EMBL:OBR86456.1};
RN [1] {ECO:0000313|EMBL:OBR86456.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:OBR86456.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Cryptococcus dejecticola CBS10117.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:WWC59886.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:WWC59886.1};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Litvintseva A., Chen Y., Heitman J., Sun S., Springer D.,
RA Dromer F., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A.,
RA Alvarado L., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:WWC59886.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 10117 {ECO:0000313|EMBL:WWC59886.1};
RA Coelho M.A., David-Palma M., Shea T., Bowers K., McGinley-Smith S.,
RA Mohammad A.W., Gnirke A., Yurkov A.M., Nowrousian M., Sun S., Cuomo C.A.,
RA Heitman J.;
RT "Comparative genomics of Cryptococcus and Kwoniella reveals pathogenesis
RT evolution and contrasting modes of karyotype evolution via chromosome
RT fusion or intercentromeric recombination.";
RL Submitted (FEB-2024) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; KI894029; OBR86456.1; -; Genomic_DNA.
DR EMBL; CP144532; WWC59886.1; -; Genomic_DNA.
DR RefSeq; XP_018264298.1; XM_018405804.1.
DR AlphaFoldDB; A0A1A6A8S1; -.
DR STRING; 1296121.A0A1A6A8S1; -.
DR GeneID; 28966162; -.
DR VEuPathDB; FungiDB:I303_02463; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000078595; Chromosome 3.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20339; BRcat_RBR_RNF216; 1.
DR CDD; cd20353; Rcat_RBR_RNF216; 1.
DR CDD; cd16630; RING-HC_RBR_RNF216; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR InterPro; IPR047545; BRcat_RBR_RNF216.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR051628; LUBAC_E3_Ligases.
DR InterPro; IPR047546; Rcat_RBR_RNF216.
DR InterPro; IPR047544; RING-HC_RBR_RNF216.
DR InterPro; IPR044066; TRIAD_supradom.
DR PANTHER; PTHR22770:SF47; E3 UBIQUITIN-PROTEIN LIGASE RNF216; 1.
DR PANTHER; PTHR22770; UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED; 1.
DR Pfam; PF01485; IBR; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000078595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 372..587
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 20..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..808
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..877
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 98883 MW; ABCC499F62DFCAA0 CRC64;
MPGTLSAQSS LFASSDIFVN LPAGPYHTSD DTSDDDSVLA LDEVPDYLKK NTNKDNPIAI
DSSSEDDTPQ ANQAGPSRRK RTTADLSDHG SPRTLRSSQK SKDDDEDRHN KRKRSNTADS
SQVTQDVVIA DIPSSPEAGP STPKSYLAED HLTRVIEILP DIDSEWALRA INEEMILRPG
VNPANRVVEI ALEMEGGYPR LKENKKGKDE DTNPLISGQE NEYKDPAYRS QHRFGPAYYA
RSMAQLEQDF PSIPTAHLRH TYISAHSAYV PAYLRLLEHT KLEPKPYSQL KRPRNVTRVK
TKATGLSYSS SQASEQASSG SRTNGEGPLD GIAEEFDKEL NWLHNHLVVK AEKLSEEEAR
RIATEEALAA GGGIECGCCF GETLLEDMIQ CNEGHLFCCE CATQHAETKL GEQSVSILCM
DQSDCTSPFP DSELARLLSV KSLDLYHRLK QAKDLEQAEI EGLESCPSCP FAAVIDNPNE
KLFRCMNKEC GQVTCRGCRR KEHIPRTCAE VEADLKLNNR HTVEDAMSEA LIRHCPKCAK
PYIKESGCNK IHCSKCGTMS CYICQKAVQG YQHFDQDPRE YGQGKKEGKC VLWDSEEHHQ
DAEAVRRARD TAAAEVLAAA QAGGIALNAA DLNVDLPDPF VRNQMYGGNP MVNAVRLAGG
PLPPAPALAP APLFNLNVGI RGFASPPPAL PAFNGRNRNV GPLHIVDNRQ RVMVERQAQY
MRDRRAIDEA YQDARRVNER EDWGGNLRDL AGFEENERRL QQHMDEAHRR VREEMDNHQH
RLQNIQPAPA PAPAPALAPA HAPAPDPALP GDAIAREQAL ARLHEMDDNT LQRYLEDEEE
DPIDGSYHDV DDDEEEEEDA EEIGTTDEEE LMELEALEEI RRGRYTRAA
//
