ID A0A1A8AG49_NOTFU Unreviewed; 539 AA.
AC A0A1A8AG49;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 28-JAN-2026, entry version 46.
DE SubName: Full=Suppressor of cytokine signaling 5-like {ECO:0000313|EMBL:KAF7218656.1};
DE SubName: Full=Suppressor of cytokine signaling 9 {ECO:0000313|EMBL:SBP54029.1, ECO:0000313|Ensembl:ENSNFUP00015003796.1};
GN Name=SOCS9 {ECO:0000313|EMBL:SBP54029.1};
GN Synonyms=socs9 {ECO:0000313|Ensembl:ENSNFUP00015003796.1};
GN ORFNames=G4P62_006261 {ECO:0000313|EMBL:KAF7218656.1};
OS Nothobranchius furzeri (Turquoise killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae;
OC Nothobranchius.
OX NCBI_TaxID=105023 {ECO:0000313|EMBL:SBP54029.1};
RN [1] {ECO:0000313|Ensembl:ENSNFUP00015003796.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GRZ {ECO:0000313|Ensembl:ENSNFUP00015003796.1};
RA Senf B., Petzold A., Downie B.R., Koch P., Platzer M.;
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SBP54029.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:SBP54029.1};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SBP54029.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:SBP54029.1};
RA Reichwald K., Felder M., Petzold A., Koch P., Groth M., Platzer M.;
RT "The genome of a short-lived fish provides insights into sex chromosome
RT evolution and the genetic control of aging.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAF7218656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GRZ {ECO:0000313|EMBL:KAF7218656.1};
RC TISSUE=Whole {ECO:0000313|EMBL:KAF7218656.1};
RA Willemsen D., Cui R., Valenzano D.R.;
RT "Intra-Species Differences in Population Size shape Life History and Genome
RT Evolution.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSNFUP00015003796.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; JAAVVJ010000007; KAF7218656.1; -; Genomic_DNA.
DR EMBL; HADY01015544; SBP54029.1; -; Transcribed_RNA.
DR EMBL; HAEJ01008456; SBS48913.1; -; Transcribed_RNA.
DR RefSeq; XP_015806667.1; XM_015951181.3.
DR AlphaFoldDB; A0A1A8AG49; -.
DR Ensembl; ENSNFUT00015004017.1; ENSNFUP00015003796.1; ENSNFUG00015001929.1.
DR GeneID; 107380111; -.
DR KEGG; nfu:107380111; -.
DR CTD; 100003691; -.
DR GeneTree; ENSGT00940000164285; -.
DR OMA; SYRIHTQ; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000694548; Chromosome sgr06.
DR Proteomes; UP000822369; Chromosome 7.
DR Bgee; ENSNFUG00015001929; Expressed in caudal fin and 3 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF18; SUPPRESSOR OF CYTOKINE SIGNALING 9 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000694548};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 387..482
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 477..526
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..47
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 60226 MW; DE8E777FF63D18EE CRC64;
MSLPNDSGNR GKERERGARP KVRQSRSEER RDAGSGRKNG KGKKKGVSLH ETVAERPVSD
GFEYGELLNE LEARSLNSSS PQDSWRWQGS DVVSSSLGPD PAARPGLGTV SSTTDLPSLS
EAEGRGSNAS RTLRQKIQDA VGQCFPIKTL SAAAPAPAPP PQAFSSSAAC ASSRRKIHLS
ELMLDDCPFP VGSELAQKWY LIKQHTAPIT QPPLLDSAVV CSAPTSAMAV AVEDVDDKLR
ERRRISIEQG VEPPPNAEIH TFEVTAQINP LYKHGPKLAH GMNELAGTDG VSAQQQQQLL
IQRQQQHQLL LQSCLDTLDE VAASTSTPEV NSDPLVDPDL KMTSLTSRAL RPQTEHHKSH
EGYRIHTQID YIHCLVPDLL QITNLPCYWG VMDRYEAETL LEGKPEGTFL LRDSAQEDYL
FSVSFRRYGR SLHARIEQWN HNFSFDVHDP SVFHAATVTG LLEHYKDPNS CMFFEPLLSN
PIHRTHPFSL QHICRAVISS YTTYDGINIL PIPNSLKKHL KEYHYKQRVR VRRMDSWWE
//
