ID A0A1A8AJ21_NOTFU Unreviewed; 521 AA.
AC A0A1A8AJ21;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE RecName: Full=Putative GTP-binding protein 6 {ECO:0000256|ARBA:ARBA00070394};
GN Name=GTPBP6 {ECO:0000313|EMBL:SBP54220.1,
GN ECO:0000313|Ensembl:ENSNFUP00015040974.1};
GN Synonyms=gtpbp6 {ECO:0000313|EMBL:KAF7204951.1};
GN ORFNames=G4P62_017615 {ECO:0000313|EMBL:KAF7204951.1};
OS Nothobranchius furzeri (Turquoise killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Nothobranchiidae;
OC Nothobranchius.
OX NCBI_TaxID=105023 {ECO:0000313|EMBL:SBP54220.1};
RN [1] {ECO:0000313|EMBL:SBP54220.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:SBP54220.1};
RA Lavstsen T., Jespersen J.S.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SBP54220.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:SBP54220.1};
RA Reichwald K., Felder M., Petzold A., Koch P., Groth M., Platzer M.;
RT "The genome of a short-lived fish provides insights into sex chromosome
RT evolution and the genetic control of aging.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAF7204951.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GRZ {ECO:0000313|EMBL:KAF7204951.1};
RC TISSUE=Whole {ECO:0000313|EMBL:KAF7204951.1};
RA Willemsen D., Cui R., Valenzano D.R.;
RT "Intra-Species Differences in Population Size shape Life History and Genome
RT Evolution.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSNFUP00015040974.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JAAVVJ010000016; KAF7204951.1; -; Genomic_DNA.
DR EMBL; HADY01015735; SBP54220.1; -; Transcribed_RNA.
DR RefSeq; XP_015829814.3; XM_015974328.3.
DR AlphaFoldDB; A0A1A8AJ21; -.
DR Ensembl; ENSNFUT00015042773.1; ENSNFUP00015040974.1; ENSNFUG00015019558.1.
DR GeneID; 107395054; -.
DR KEGG; nfu:107395054; -.
DR CTD; 8225; -.
DR GeneTree; ENSGT00390000001397; -.
DR OMA; IDVANKC; -.
DR OrthoDB; 10268034at2759; -.
DR Proteomes; UP000694548; Unassembled WGS sequence.
DR Proteomes; UP000822369; Chromosome 16.
DR Bgee; ENSNFUG00015019558; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR CDD; cd01878; HflX; 1.
DR FunFam; 3.40.50.11060:FF:000002; GTP binding protein 6 (putative); 1.
DR FunFam; 3.40.50.300:FF:000886; Putative GTP-binding protein 6; 1.
DR Gene3D; 3.40.50.11060; GTPase HflX, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030394; G_HFLX_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR032305; GTP-bd_M.
DR InterPro; IPR016496; GTPase_HflX.
DR InterPro; IPR025121; GTPase_HflX_N.
DR InterPro; IPR042108; GTPase_HflX_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03156; GTP_HflX; 1.
DR PANTHER; PTHR10229:SF0; GTP-BINDING PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10229; GTP-BINDING PROTEIN HFLX; 1.
DR Pfam; PF16360; GTP-bdg_M; 1.
DR Pfam; PF13167; GTP-bdg_N; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51705; G_HFLX; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000694548}.
FT DOMAIN 299..463
FT /note="Hflx-type G"
FT /evidence="ECO:0000259|PROSITE:PS51705"
SQ SEQUENCE 521 AA; 58871 MW; FF1A01CA3CFDC1D6 CRC64;
MITVRGLASW RSLLQRPWSC HRAVSTYRLS PPSAQHRCLG NPSTLQSRLF NMSASWLKSK
DDFSSSYTVD EEDEDILEDS EVEELFQQQV PAGIGQGQHR VFIVHPDVKW GSRKQRLTTA
ELMMAEAEGL VHTLDNWTVV DKIILSTKTP EKKRIFGKGN FQLLTEKIRE TVGISAVFVN
VDRLSPSSER EFEEAWGIKV FDRYSVVLHI FRCNARTKEA KLQISLAEIP LLRSRLKNEM
ANLDQQGGGS RYIGGSGETV SEVQQRLLKE REMKIRSALE KLRKKRHLLR SQRKHREFPT
VSVLGYTNCG KTTLIKALTG DSGLQPRNQL FATLDVTVHA GQLPSHMTVL YVDTIGFLSQ
LPHQLIDSFS ATLEDIKHSD LLVHVRDISH PETVNQKVNV LSVLKNLQIP DQLMSSMIEV
HNKIDLVDNY QSAEPGAVLI SALEQRGLDK LKTTVEEEII KSTGNQILHL KVNLSTPQLS
WLYREATVQD IQVNADEGTA VVKVIISAAA HGRYRKQFES R
//
