ID A0A1B7LH15_9FIRM Unreviewed; 637 AA.
AC A0A1B7LH15;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=A6M21_06155 {ECO:0000313|EMBL:OAT85494.1};
OS Desulfotomaculum copahuensis.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales;
OC Desulfotomaculaceae; Desulfotomaculum.
OX NCBI_TaxID=1838280 {ECO:0000313|EMBL:OAT85494.1, ECO:0000313|Proteomes:UP000078532};
RN [1] {ECO:0000313|EMBL:OAT85494.1, ECO:0000313|Proteomes:UP000078532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMa1 {ECO:0000313|EMBL:OAT85494.1,
RC ECO:0000313|Proteomes:UP000078532};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAT85494.1}.
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DR EMBL; LYVF01000062; OAT85494.1; -; Genomic_DNA.
DR RefSeq; WP_066666841.1; NZ_LYVF01000062.1.
DR AlphaFoldDB; A0A1B7LH15; -.
DR STRING; 1838280.A6M21_06155; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000078532; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:OAT85494.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000078532}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 637 AA; 69964 MW; 32B0236A966CB241 CRC64;
MNHLIIGTAG HVDHGKTMLV KALTGVDTDR LKEEKDRGIS IELGFASLKL PGGRLAGIVD
VPGHERFIKN MLAGAGGMDL VLLVIAADEG VMPQTREHMD IIQLLQINRG VVVLTKVDLV
DEEWLAMVRD DVKSFLQGTV LENAPLVEVS AATGQGIGEL LRVIDEQAGR VMERPAAGRV
RLPVDRAFSV TGFGTVVTGT LWSGELHLGD TMELMPRGLT TRVRSLQVHG KKVDTARAGQ
RVAANLTGLE VEQVSRGSVL AAPGSLTPSY RLDVRLLLLK SAAKALKNRA RIRLYLGTAE
TLGRVILLDR EEMAPGETAL AQLELEEVAV AQRGDRFVIR SYSPMRTIGG GAVIDPVPHK
HKRLREEVLN GLATRERGTP AELVEQQLPD RPALPTGDEI AAAAGLTAEE AGTALNRLIE
EGRAVRIPAE TSDYYAARDA YARWAKELQA TLSAYHRGHP LRDGYPREEL RSRQFPGLNS
KQLQFLLQCM EKDGLVQLNA QSVARSGFTP HLEPALQKTS DQLEKTFRDA GFQPPAWTGE
ARRAGLDADQ ARELLAYLLR RGILIKVADD LYFHRADLER AKELLLAHLA AKGNITVGEA
RDLWQTTRKY ALPLLEYFDR ERITRRVGDN RVAGRAQ
//
