ID A0A1D2YSJ5_9BACI Unreviewed; 574 AA.
AC A0A1D2YSJ5;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 1.
DT 18-JUN-2025, entry version 41.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BHF71_03720 {ECO:0000313|EMBL:OEF97304.1};
OS Vulcanibacillus modesticaldus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Vulcanibacillus.
OX NCBI_TaxID=337097 {ECO:0000313|EMBL:OEF97304.1, ECO:0000313|Proteomes:UP000243739};
RN [1] {ECO:0000313|EMBL:OEF97304.1, ECO:0000313|Proteomes:UP000243739}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BR {ECO:0000313|EMBL:OEF97304.1,
RC ECO:0000313|Proteomes:UP000243739};
RA Abin C.A., Hollibaugh J.T.;
RT "Draft genome sequence for the type strain of Vulcanibacillus modesticaldus
RT BR, a strictly anaerobic, moderately thermophilic, and nitrate-reducing
RT bacterium from deep sea-hydrothermal vents of the Mid-Atlantic Ridge.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC raft {ECO:0000256|ARBA:ARBA00004314}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004314}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEF97304.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MIJF01000067; OEF97304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1D2YSJ5; -.
DR STRING; 337097.BHF71_03720; -.
DR Proteomes; UP000243739; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:TreeGrafter.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0030295; F:protein kinase activator activity; IEA:TreeGrafter.
DR GO; GO:0007234; P:osmosensory signaling via phosphorelay pathway; IEA:TreeGrafter.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR FunFam; 3.30.565.10:FF:000023; PAS domain-containing sensor histidine kinase; 1.
DR FunFam; 1.10.287.130:FF:000001; Two-component sensor histidine kinase; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR041328; HisK_sensor.
DR InterPro; IPR052545; Light-responsive_reg.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR42878:SF3; HISTIDINE PROTEIN KINASE SAES; 1.
DR PANTHER; PTHR42878; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF18698; HisK_sensor; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000243739};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 9..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 189..241
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 355..574
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 574 AA; 65021 MW; A9237746C024EBC0 CRC64;
MTRSVVGKLW ITIIAIVAVL FLLLSTIVFK YFDNHYYTQQ SNSLSALGEE ISLIIEKNPN
REKAIEIIDD ILRAYETNMV IIKKDATGKY PQIEKLFSPE DIKLILENQK NVVRISDVSY
KYYLTFDKVD DFLAIAYPLS ENGKDIGVII LYQSLERLYE VTNNLKKILL LFVGIASVIT
TFFSFFLSYK ITAPIRQMKK AAVQMARGNF KHKISIRTTD EIGELADSFN KMASQLAETV
QALSDEKEKL TNILKSMADG VITVNRRGDI IVTNPPADKL LLWEKELPDS IKEMLETVIK
QEVNVKKDIN LHGRILSVVM APLFSDKVVN GAVMLLRDVT YERKLNKLRQ DFLANVSHEL
RTPISMIQGY SEAIIDDMVL SPEETKELTH IIYEESLRMG RLVNDLLDLA RMESGMYQIQ
YSKTDIKLLI DKMIRKFSSL AQEHKIELIS DYDPKLPEVY VDGDRIEQVL TNLVDNAIRH
TKNGGKITIR AKLKSSDNFL LEVSDTGEGI PEQDIPYVFE RFYKADKART RGNSGTGLGL
SIVKNIVNSH GGTISVDSKI GQGTTFSIII PTNI
//
