ID A0A1D8GPG3_9FIRM Unreviewed; 631 AA.
AC A0A1D8GPG3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=Gferi_26445 {ECO:0000313|EMBL:AOT72785.1};
OS Geosporobacter ferrireducens.
OC Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales;
OC Thermotaleaceae; Geosporobacter.
OX NCBI_TaxID=1424294 {ECO:0000313|EMBL:AOT72785.1, ECO:0000313|Proteomes:UP000095743};
RN [1] {ECO:0000313|EMBL:AOT72785.1, ECO:0000313|Proteomes:UP000095743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IRF9 {ECO:0000313|EMBL:AOT72785.1,
RC ECO:0000313|Proteomes:UP000095743};
RA Kim S.-J.;
RT "Genomic analysis reveals versatility of anaerobic energy metabolism of
RT Geosporobacter ferrireducens IRF9 of phylum Firmicutes.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP017269; AOT72785.1; -; Genomic_DNA.
DR RefSeq; WP_069981094.1; NZ_CP017269.1.
DR AlphaFoldDB; A0A1D8GPG3; -.
DR STRING; 1424294.Gferi_26445; -.
DR KEGG; gfe:Gferi_26445; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000095743; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:AOT72785.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000095743}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 631 AA; 72114 MW; F213DDC1949A6B87 CRC64;
MKNVIVGTAG HIDHGKTTLI KALTGTDTDR LLEEKKRGIT IDLGFTHFDL PSGRRAGIID
VPGHEKFIKN MLAGVGGIDI VLLVIAADEG FMPQTQEHLD ILTILEVKKG IIVLTKVDLV
DPEWLSLVQE EIREKVKDTF LRDAPMLAVS STQGQGLKEL VERIDFYTEE TEEKNTSIPF
RLPVDRVFTM SGFGTVITGT LIEGSVHEGD QMTIYPQELT AKVRNLHVHG KKVESAYAGQ
RVAINLSGVK KEDILRGNVA AEQNSMKETM MLDVKLNMLK HAERIIDNRD RLRLYHGTAE
VLCRVVLLDR EEIKPGESCY AQLRLEESIV AKRGDHFVIR FYSPMETLGG GVILEPNPIK
HKRFKADTLE ELKVKEEGSP EQILEKVILR FNDAFANIGF YATQTGLSEN TILAIVDKLT
EKGIIRKFSG TVPVHIDYLT KLEDSIIKVL QNYHNSNPLK IGMGKEELRN KLKIKIKGKL
YDELLEHFEN NQIIRLHNNF TALADFEVKY SPEQLVILEE IDRLYLEREF QTPAPEDFLN
SKKNEQKYRE VLEALIEKKQ LIKINEDILL HVENYEKAKE MLKQFIKENG QITLSEFRDL
IHTTRKYALP LIENFDQNKI TKRIDEKRVL Y
//
