ID A0A1E3HFY2_9TREE Unreviewed; 1066 AA.
AC A0A1E3HFY2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JAN-2026, entry version 35.
DE RecName: Full=ATP-dependent RNA helicase DOB1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=L202_06454 {ECO:0000313|EMBL:ODN75269.1};
OS Cryptococcus amylolentus CBS 6039.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus.
OX NCBI_TaxID=1295533 {ECO:0000313|EMBL:ODN75269.1, ECO:0000313|Proteomes:UP000094065};
RN [1] {ECO:0000313|EMBL:ODN75269.1, ECO:0000313|Proteomes:UP000094065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 6039 {ECO:0000313|EMBL:ODN75269.1,
RC ECO:0000313|Proteomes:UP000094065};
RA Cuomo C., Litvintseva A., Heitman J., Chen Y., Sun S., Springer D.,
RA Dromer F., Young S., Zeng Q., Chapman S., Gujja S., Saif S., Birren B.;
RT "Evolution of pathogenesis and genome organization in the Tremellales.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ODN75269.1}.
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DR EMBL; AWGJ01000010; ODN75269.1; -; Genomic_DNA.
DR RefSeq; XP_018990919.1; XM_019140944.1.
DR AlphaFoldDB; A0A1E3HFY2; -.
DR STRING; 1295533.A0A1E3HFY2; -.
DR GeneID; 30157763; -.
DR OrthoDB; 64767at2759; -.
DR Proteomes; UP000094065; Unassembled WGS sequence.
DR GO; GO:0031499; C:TRAMP complex; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IEA:TreeGrafter.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18024; DEXHc_Mtr4-like; 1.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000083; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 3.40.50.300:FF:000141; ATP-dependent RNA helicase DOB1; 1.
DR FunFam; 2.40.30.300:FF:000001; Mtr4 exosome RNA helicase; 1.
DR FunFam; 1.10.3380.30:FF:000002; superkiller viralicidic activity 2-like 2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000094065};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 152..308
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 387..591
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 619..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 369..379
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 120228 MW; 6ED643F3720804FB CRC64;
MPDSTKKATK SKSSKQNLNP EKKKRSKTTP TPSPRPSKSA KLVEINDDDD PMAALENEQN
EDKDPMEALE EEQIVPKMAD EYEVQAEREV AAAKDSLDSS GDKEPLKLVH QVRHQVAIPP
DYPYVPINQH KRLDPPARTY KFELDPFQYV STSCIERNES VLVSAHTSAG KTVVAEYAIA
TCLREGKRIV YTSPIKALSN QKFREFTETF GDVGLMTGDV TIKPEASCLV MTTEILRSML
YRGSEVMREV AWVVFDEVHY MRDKERGVVW EETIILLPHS VRYVFLSATI PNSMEFAEWI
TQTHEQPCHV VYTDFRPTPL QHYLFPAGSE GIYLVVDEKS NFRDDNFQKA MASLAQGQGE
DPADPNSGRN KKGKTKKGGA MKGETSDIYK IVTLIMRRNL NPVIIFAFSK RECEDLAMQM
QKFDFNTPDE ASTVAQVFEN AIGSLSEDDK KLSQIEGILP LLKRGIGIHH GGLLPILKEV
IEILFQEGLI KALFATETFS IGLNMPAKTV VFTSVRKFDG KDFRNLSGGE YIQMSGRAGR
RGLDARGIVI MMCDEKIEPE AAKGMVKGQA DRLDSAFHLG YNMIINLMRV EGVSPEFMLE
RCFFQFQNSM SVPVLEKQLK EAEVERDAIA VEREDEIEEY YELRQQLKER GQDFQAVITH
PAYCLRFLQP GRLVEVREGE KDFGWGVVIA FNKVVNPRGR PPIWTDQDPP QKQYVVDILT
RIASGSSVPK DRSASELSPP DEGDKGDVAI IACSLSTLQA ISQYRINLPK DLRSQQDKNA
AFRAVGEIKK RMPDGPPLLD PIKSMGIEDK SFKDLVKKIS ILENKLQSLP VTTSSELPRL
YDLYDRKQQS INTVKSLKRR INSVHDILQL EELKSRKRVL RRLGFTTADD VVEMKGRVAC
EISTGDELML TEMMFGGTFG TLTPEQCAAL LSCFVFQEKS EAKVRLKEEL ATPLRTLQET
AKRIAKVSTE SGIALVEDEY VQSFKVEMMD VVLQWCKGAK FSEICAMTDI FEGSIIRCFR
RLQELIRQMG AAAHAIGNTE LEKKFGESMD LLERPNTVVF NPSLYL
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