ID A0A1E5G447_9FIRM Unreviewed; 645 AA.
AC A0A1E5G447;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=BHF68_13530 {ECO:0000313|EMBL:OEF97845.1};
OS Desulfuribacillus alkaliarsenatis.
OC Bacteria; Bacillati; Bacillota; Desulfuribacillia; Desulfuribacillales;
OC Desulfuribacillaceae; Desulfuribacillus.
OX NCBI_TaxID=766136 {ECO:0000313|EMBL:OEF97845.1, ECO:0000313|Proteomes:UP000094296};
RN [1] {ECO:0000313|EMBL:OEF97845.1, ECO:0000313|Proteomes:UP000094296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AHT28 {ECO:0000313|EMBL:OEF97845.1,
RC ECO:0000313|Proteomes:UP000094296};
RA Abin C.A., Hollibaugh J.T.;
RT "Draft genome sequence for the type strain of Desulfuribacillus
RT alkaliarsenatis AHT28, an obligately anaerobic, sulfidogenic bacterium
RT isolated from Russian soda lake sediments.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEF97845.1}.
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DR EMBL; MIJE01000003; OEF97845.1; -; Genomic_DNA.
DR RefSeq; WP_069642476.1; NZ_MIJE01000003.1.
DR AlphaFoldDB; A0A1E5G447; -.
DR STRING; 766136.BHF68_13530; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000094296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:OEF97845.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000094296}.
FT DOMAIN 3..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 645 AA; 72237 MW; C531EF22057F8B84 CRC64;
MDNKHIIMGT AGHIDHGKTT LIRALTGKET DYIKEEKERG ISIDIGFAPF TLNDGRTIGV
IDVPGHEKFI KNMLAGIGGI DFVLLIIDVN EGIMPQTTEH FHILNLLGIK KGIIVLTKAD
LAEDEWVDFV KEEVREQFAT TAFKDAPIVA VSATTGQGID ELKQEIAKLA DTIKTKETIA
AFRMPIDRIF SISGFGTVVT GTAISGMVNI GDKIELLPDG QEGRIRGVQH HSSKVETGYA
GQRLALNISG LESAEIERGM VVAEPSIFQP TNRIDVRIQM IDPSPRELAN RSRVRIYTGS
SEVFGRVVLL ESDTLNSGQA GLAQLKLESP IVVEPKDRLI IRFYSPMETI AGGVVIEPHP
AKFYKRFHEQ TLKELRMKEK GGLAERILEN LKNIGVANLK TLTTDVKASS PDIVEKELKG
LISSKQVHFV EALAMYILRA EYQYILKTTI SLIEAYYKQH KFTRFAPKGQ LHSEIVAATK
KTAYKPKVLE AIWNEQEFQE SIESVGDSLA LRGYQVQLTA EDEQLLQQLT KIYSDAGISV
PSNKEVLERI PALKSEQRLL DLLMYLVEQD TLVFVADGMF YHRQTIEHLV EVLQALSAKK
EKFTVSDFRD EIDSSRKYTV ALLEYFDREK ITRRVGDERV LLKKS
//
