ID A0A1G6CK21_9FLAO Unreviewed; 806 AA.
AC A0A1G6CK21;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 02-APR-2025, entry version 25.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=SAMN03097699_0751 {ECO:0000313|EMBL:SDB33226.1};
OS Flavobacteriaceae bacterium MAR_2010_188.
OC Bacteria; Pseudomonadati; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=1250295 {ECO:0000313|EMBL:SDB33226.1, ECO:0000313|Proteomes:UP000199442};
RN [1] {ECO:0000313|EMBL:SDB33226.1, ECO:0000313|Proteomes:UP000199442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mar_2010_188 {ECO:0000313|EMBL:SDB33226.1,
RC ECO:0000313|Proteomes:UP000199442};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
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DR EMBL; LT629302; SDB33226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1G6CK21; -.
DR STRING; 1250295.SAMN03097699_0751; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000199442; Chromosome I.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04865; LigD_Pol_like_2; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014143; NHEJ_ligase_prk.
DR InterPro; IPR052171; NHEJ_LigD.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1.
DR PANTHER; PTHR42705:SF3; ATP-DEPENDENT DNA LIGASE; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000199442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 285..407
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
SQ SEQUENCE 806 AA; 92137 MW; 9F88FA8E445A08CC CRC64;
MPLGEYNKKR DFKSTQEPEG VEDLSNKWRF VIQRHQASRL HYDLRLEIEG VLKSWAIPKG
PSMNPKDKRL AVQTEDHPVK YLTFKGDIPK GNYGAGHMDI WDSGTFSIYE EAAEGPVEKQ
FKKGNLKVEF FGKKVKGKFA LVKTRQEGKQ QHWLLIKKQD DFSTDLHYDS EIFVPVESQS
NSSSPIKKLD IKGIVKPMLA ESATEIFADP NWIYEFKWDG YRMISQIKNG KVEMYSRNGI
NYNSKFAKVH QELSAIPHDV ILDGEIVITD GKGLPKFQKL QNYDPQGTKG RLMYYVFDVL
HLNGHDTIEL PLLDRKSLLP EILEGLEHVV LCDHIEAMGI AFYERAVKLG MEGVIAKKSD
SKYSPGFRSK DWLKIKEIDS TEALICGYTT GSGRGKLFGS LILGQYRNDD LVYIGNVGSG
FNSKEQKDLM KMFQPLETEK SSFNKKPNLK GREPHWMTPQ LLCEVNFTEW TKSGVLRHPT
YKGLRFDKLN PVASRTSKNI KPEKPKDVAG NLDVSGIKVP FTNLDKIYWP ESGFRKYDLI
DYYLKVSDFI LPYLKDRPQN LHRHPNGINK EGFYQKDNEF LPDWADSVSI YSKSAEKEIN
YLLCNNEATL LYMANLGCIE INPWSSRIVD LDKPDYTVID IDPSDKNTFD EVLECARVAK
EILDQAQVEA YCKTTGKSGL HIFIPLGGKY SYDEARTFTQ LLCVYINERL PKLTSLERAV
MKRKNQIYLD FMQNRRGQTL ASAYCARPVE GARVSTPVSW KEIEKGFEKE EFTILTLPKR
LASIGDIFIG VVSKGINMEH ALSNLS
//
