ID A0A1G6YKL2_9BACT Unreviewed; 653 AA.
AC A0A1G6YKL2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN05661003_10288 {ECO:0000313|EMBL:SDD91044.1};
OS Desulfuromonas thiophila.
OC Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfuromonadia;
OC Desulfuromonadales; Desulfuromonadaceae; Desulfuromonas.
OX NCBI_TaxID=57664 {ECO:0000313|EMBL:SDD91044.1, ECO:0000313|Proteomes:UP000243205};
RN [1] {ECO:0000313|Proteomes:UP000243205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8987 {ECO:0000313|Proteomes:UP000243205};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FNAQ01000002; SDD91044.1; -; Genomic_DNA.
DR RefSeq; WP_092076028.1; NZ_FNAQ01000002.1.
DR AlphaFoldDB; A0A1G6YKL2; -.
DR STRING; 57664.SAMN05661003_10288; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000243205; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SDD91044.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000243205}.
FT DOMAIN 6..179
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 653 AA; 72278 MW; D7457308910BA75B CRC64;
MTTATIRHLI IGTAGHVDHG KTQLIRALTG METDRLKEEQ QRGISIDLGF ACFRLPGDIE
AGVIDVPGHE RFINNMLAGI GGIDLVMLVI DANEGVMPQT REHLNILELL QIQRGIIVLT
KMDLVEPDWA DIVEEEIRET LSGTFLAKAP LCRVSALTGE GLPQLRATLA ACAAELRPRD
ADGPMRLPVD RHFSVAGFGT VVTGTLLSGR VATGDLVEVL PAGERVRVRD VQVHGQRQTV
ALCGQRVALN LAGLEREQLQ RGAVIATPGV FEQTSRLDAR LTLLAEAPRP VRFRDPVHFY
LGTAHVVGLV ALLDRDELKP GESALVQFHL DRPLVAHRQD RFIIRSYSPM TTIGGGLVID
PRPVKHKRFR PQVLQALKEL ESGEGTFVLQ KLNDLQVARV KDLEQLSGLS RERIGLLLQQ
LQNNGAVVAL ADQWASQSTV QLWHQRLRQQ VETFHRQQPL LPGMGHAPLK ASLPAALNLK
AFDQLLYQAG LQRCGEWVQL PDFVPQPSAA QQRQLDRLLQ VYGQAGVQAS GRRDMLAQAA
ISDDEADALL GYLFYRGELI RLNDDTYFHR DSYLQALTVL LDHFRQHDSL TLAQYRDLLG
SARKPVQALL EHFDERKFCL RQGDSRRPWH LPASAAAALT PPASLAPTEE NSS
//
