ID A0A1G9HAB0_9ACTN Unreviewed; 323 AA.
AC A0A1G9HAB0;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 02-APR-2025, entry version 21.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:SDL09938.1};
GN ORFNames=SAMN05421869_12244 {ECO:0000313|EMBL:SDL09938.1};
OS Nonomuraea jiangxiensis.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=633440 {ECO:0000313|EMBL:SDL09938.1, ECO:0000313|Proteomes:UP000199202};
RN [1] {ECO:0000313|EMBL:SDL09938.1, ECO:0000313|Proteomes:UP000199202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.6533 {ECO:0000313|EMBL:SDL09938.1,
RC ECO:0000313|Proteomes:UP000199202};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; FNDJ01000022; SDL09938.1; -; Genomic_DNA.
DR RefSeq; WP_090943171.1; NZ_FNDJ01000022.1.
DR AlphaFoldDB; A0A1G9HAB0; -.
DR STRING; 633440.SAMN05421869_12244; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000199202; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199202}.
FT DOMAIN 4..144
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 174..288
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 223..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 34749 MW; 424B502D83B04F02 CRC64;
MRYIVIGAGA VGGTIGARLH QGGHEVLLIA RGAHYEALRR DGLRLVTPDS DETLDIPAAD
GPVPTRDDDV LILATKSQDT VAALAPWPSG LPVVCAQNGV DNERMVLRRF ERVYGMCVWL
PAQHMEPGLV EAYGHPNSGM LHVGRYPQGV DELTTQIVTD LGKRDLVAHA APDVMRWKYG
KLLGNLGNAV EALLGHVPGL ENVLRRAREE AMTVLRAAGI DYSTPEEEAE SRGDQVNGRP
IEGSKRGGGS SWQSLARGSG SIEADYLNGE IVLLGRLHGV PTPVNEVLRR EANRHAREKL
PPGSMPMETL LALIDGRSAA GSR
//
