ID A0A1H1KW44_9BACT Unreviewed; 419 AA.
AC A0A1H1KW44;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 02-APR-2025, entry version 20.
DE SubName: Full=Concentrative nucleoside transporter, CNT family {ECO:0000313|EMBL:SDR66222.1};
GN ORFNames=SAMN05444173_0170 {ECO:0000313|EMBL:SDR66222.1};
OS Opitutus sp. GAS368.
OC Bacteria; Pseudomonadati; Verrucomicrobiota; Opitutia; Opitutales;
OC Opitutaceae; Opitutus.
OX NCBI_TaxID=1882749 {ECO:0000313|EMBL:SDR66222.1, ECO:0000313|Proteomes:UP000199432};
RN [1] {ECO:0000313|EMBL:SDR66222.1, ECO:0000313|Proteomes:UP000199432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GAS368 {ECO:0000313|EMBL:SDR66222.1,
RC ECO:0000313|Proteomes:UP000199432};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033}.
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DR EMBL; LT629735; SDR66222.1; -; Genomic_DNA.
DR RefSeq; WP_091054693.1; NZ_LT629735.1.
DR AlphaFoldDB; A0A1H1KW44; -.
DR STRING; 1882749.SAMN05444173_0170; -.
DR OrthoDB; 9766455at2; -.
DR Proteomes; UP000199432; Chromosome i.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:TreeGrafter.
DR InterPro; IPR008276; C_nuclsd_transpt.
DR InterPro; IPR011657; CNT_C_dom.
DR InterPro; IPR002668; CNT_N_dom.
DR InterPro; IPR011642; Gate_dom.
DR PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR Pfam; PF07670; Gate; 1.
DR Pfam; PF07662; Nucleos_tra2_C; 1.
DR Pfam; PF01773; Nucleos_tra2_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000199432};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 29..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..80
FT /note="Concentrative nucleoside transporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01773"
FT DOMAIN 101..199
FT /note="Nucleoside transporter/FeoB GTPase Gate"
FT /evidence="ECO:0000259|Pfam:PF07670"
FT DOMAIN 209..416
FT /note="Concentrative nucleoside transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07662"
SQ SEQUENCE 419 AA; 44215 MW; 5FC0CE5F9677C765 CRC64;
MDRLHGLLGV AFILGIAILF SNNRSRINWR LVGTGIALQV VIALLIFKVG PVARFFSILG
HGMGKLEEFA RQGAAFVYGG IIVDQFGQTG NYLAGGFVFA FNVTATIILV CALVAILYHF
GIMQRVVAII ARAMNFVMRV SGAEALSNVA SAFVGQVEAQ VMIRPYLAGM TNSELLASMS
GSLACIAGGI LVVYANMGAA AGMDLAPKLI TASLMAAPGA LVIAKIVFPE TQESQTMGTV
KLEVKSGYSN VIDAVSHGAG DGFKIAMNVI AMLIGFIAVI ACIDWILVAI GHLFNPGFDL
TLNWIFGKFF YPMAWAMGVP SEDINNVATL LGQKLTINEF VAFQNLTTHR VPIVTEKGLL
ILSIAICGFA NFSSVGMQIG GIGALAPERR TDLAKLGLKA LLCGTLASYL SATLAGIII
//
