ID A0A1H1L504_9ACTN Unreviewed; 596 AA.
AC A0A1H1L504;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE SubName: Full=Selenocysteine-specific elongation factor {ECO:0000313|EMBL:SDR69105.1};
GN ORFNames=SAMN04488543_0058 {ECO:0000313|EMBL:SDR69105.1};
OS Friedmanniella luteola.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Friedmanniella.
OX NCBI_TaxID=546871 {ECO:0000313|EMBL:SDR69105.1, ECO:0000313|Proteomes:UP000199092};
RN [1] {ECO:0000313|EMBL:SDR69105.1, ECO:0000313|Proteomes:UP000199092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21741 {ECO:0000313|EMBL:SDR69105.1,
RC ECO:0000313|Proteomes:UP000199092};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; LT629749; SDR69105.1; -; Genomic_DNA.
DR RefSeq; WP_091408510.1; NZ_LT629749.1.
DR AlphaFoldDB; A0A1H1L504; -.
DR STRING; 546871.SAMN04488543_0058; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000199092; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SDR69105.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000199092}.
FT DOMAIN 1..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 596 AA; 61990 MW; 3C0262F63CC91BAA CRC64;
MHVVATAGHV DHGKSTLVRA LTGMEPDRFA EEQRRGMTID LGYAWTTLDG PPGSDRTLAF
VDVPGHERFI GTMLAGLGPA PAVMFVVAAD EGWRRQSTEH LAAVDALGLT DGLLVVTRAD
LADPGPAIAE AQAQLAASSL GRVPAVAVSG RTGAGLPGLR AALADLVGRL PAPRTHGRLR
LWVDRSFTIR GAGTVVTGTL GAGRLRVGDT LQLGGRRVRV RGLQTLGETA GNVAAVARVA
VNLRGVEVDE VGRGDALLTP DAWPSTSAVD VRLHPATGTV ADLPAELVLH AGTAAVPVRL
RPLGGSAARL TLHAALPLEP GDRVVLRDPG RHAVAAGAVV LDADPPELRR RGAAAARADD
LERATEAAAG EQLAEQVRRR GAVRRSELAA LGVPTDDVGL VEVSGAWLVD PGVWSGWQQA
LGAAVDAQAR AHPLDPRLSV EAARREVGVP DRALLLAAAA AAGLEHADGR LARPGAGDHL
GPAEAGLARL AAHLEADPFA APEKGDLERW GLGVAELAAA ERVGRVVRLS PDVVLLTTGP
ARAMRVLSGL AQPFTLSEAR QALGTTRRVA VPLLEHLDRR GWTVRVDGQL RRVKGR
//
