ID   A0A1H2R6K8_9BACI        Unreviewed;       402 AA.
AC   A0A1H2R6K8;
DT   22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 1.
DT   02-APR-2025, entry version 18.
DE   RecName: Full=Nucleoside permease {ECO:0000256|RuleBase:RU362018};
GN   ORFNames=SAMN05421781_0609 {ECO:0000313|EMBL:SDW14770.1};
OS   Marinococcus luteus.
OC   Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC   Marinococcus.
OX   NCBI_TaxID=1122204 {ECO:0000313|EMBL:SDW14770.1, ECO:0000313|Proteomes:UP000199488};
RN   [1] {ECO:0000313|EMBL:SDW14770.1, ECO:0000313|Proteomes:UP000199488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23126 {ECO:0000313|EMBL:SDW14770.1,
RC   ECO:0000313|Proteomes:UP000199488};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the concentrative nucleoside transporter (CNT)
CC       (TC 2.A.41) family. {ECO:0000256|ARBA:ARBA00009033,
CC       ECO:0000256|RuleBase:RU362018}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FNNC01000001; SDW14770.1; -; Genomic_DNA.
DR   RefSeq; WP_091610977.1; NZ_FNNC01000001.1.
DR   AlphaFoldDB; A0A1H2R6K8; -.
DR   STRING; 1122204.SAMN05421781_0609; -.
DR   OrthoDB; 9766455at2; -.
DR   Proteomes; UP000199488; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:TreeGrafter.
DR   InterPro; IPR008276; C_nuclsd_transpt.
DR   InterPro; IPR018270; C_nuclsd_transpt_met_bac.
DR   InterPro; IPR011657; CNT_C_dom.
DR   InterPro; IPR002668; CNT_N_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   NCBIfam; TIGR00804; nupC; 1.
DR   PANTHER; PTHR10590; SODIUM/NUCLEOSIDE COTRANSPORTER; 1.
DR   PANTHER; PTHR10590:SF4; SOLUTE CARRIER FAMILY 28 MEMBER 3; 1.
DR   Pfam; PF07670; Gate; 1.
DR   Pfam; PF07662; Nucleos_tra2_C; 1.
DR   Pfam; PF01773; Nucleos_tra2_N; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362018};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199488};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362018};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362018}; Transport {ECO:0000256|RuleBase:RU362018}.
FT   TRANSMEM        6..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        33..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        87..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        249..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        283..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        343..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   TRANSMEM        380..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362018"
FT   DOMAIN          8..80
FT                   /note="Concentrative nucleoside transporter N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01773"
FT   DOMAIN          90..187
FT                   /note="Nucleoside transporter/FeoB GTPase Gate"
FT                   /evidence="ECO:0000259|Pfam:PF07670"
FT   DOMAIN          192..398
FT                   /note="Concentrative nucleoside transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07662"
SQ   SEQUENCE   402 AA;  42690 MW;  41D8F079FBD497C1 CRC64;
     MNILWGLMGI VFVLFLAFLL SSRKKSIRFR PVLVGLLFQL VFAFLVLGST WGRAAFEWLV
     VRVQDVIDTA QEGYIFLFGE EITDTGAFAF TVLPVIIFFS SLIGILYYIG VMQVIIKFIG
     GILSAMLKTS KAESMSAAAN VFVGQTEAPL VVRPFLANMT KSELFAVMTG GLGSVAGSVL
     FGYAGLGIPL DYLLAASFMA APGGLIIAKV IFPEPDLSQT TDEIEIEKDT ESHNVIDAAA
     RGASTGLQLA LNVGAMLIAF VALIAMINLL LGWITGWFGA DGITLELLLG YVFAPVAFMI
     GVPWSEALQA GGFIGQKLVL NEFVAYANFA PEIDSFSEKS QAIITFALCG FANLSSLAII
     LGGFASLAPT RRNDIAQMGL KAVAAGALVS LLSASIAGMF VL
//