ID A0A1H4C565_9BACT Unreviewed; 637 AA.
AC A0A1H4C565;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 28-JAN-2026, entry version 30.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN05660420_02434 {ECO:0000313|EMBL:SEA55477.1};
OS Desulfuromusa kysingii.
OC Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfuromonadia;
OC Desulfuromonadales; Geopsychrobacteraceae; Desulfuromusa.
OX NCBI_TaxID=37625 {ECO:0000313|EMBL:SEA55477.1, ECO:0000313|Proteomes:UP000199409};
RN [1] {ECO:0000313|EMBL:SEA55477.1, ECO:0000313|Proteomes:UP000199409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7343 {ECO:0000313|EMBL:SEA55477.1,
RC ECO:0000313|Proteomes:UP000199409};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FNQN01000007; SEA55477.1; -; Genomic_DNA.
DR RefSeq; WP_092348862.1; NZ_FNQN01000007.1.
DR AlphaFoldDB; A0A1H4C565; -.
DR STRING; 37625.SAMN05660420_02434; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000199409; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SEA55477.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000199409}.
FT DOMAIN 4..177
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 637 AA; 70562 MW; 4A6459B2A410C931 CRC64;
MAAEGHFIIG TAGHVDHGKS ALIRALTGIE TDRLGEEKER GISIELGFAP LDLGGGQVAG
VVDVPGHEKF IPQMLSGIAG IDLVLLVIDA NEGVMPQTHE HLQIMQLLQL QKGILVLSKC
DLVEPDWLDI VEEEVREQVA GTFLEKAPCC RVSSVTGEGL SALMDVVREQ LSHVVPRDSG
GAVRLPVDRC FSISGFGTVV TGTLTSGQIK TGDTLEILPA AILARVREAQ VHDKPAPEVF
AGQRVALNLS GVNRDQIPRG SVVGTPGLFR ASQRVDVRVQ LLEDAPRAIK FRDPVHFHLG
TGRSVGQVVL LDRDELVPGD EALVQITLDH PLLVHRGDRF IIRSYSPMIT IGGGMVIDAE
PQKHKRFRAE VTQRLHDLAS GDLGFWLQKL DELEVARVKD LEKQTGTGRQ QLLQGLEKLQ
EAGQVELLAE QWVLADRVRS WKQQFPRIVA EYQQQHHLRH GIPRATLQAQ LSKKLAPKGF
EVLLQWALAE KLIVLNRDLV ATPDWQPQPT SAELKILKQL DDCFRAAGFQ VKNNKEVLLS
LGFDGLDSEA YFSYLVLEGS LVRLNQESSL HMDSYRQAEQ LLVTTFQQQE TVTLAEFRDK
LGSGRKLTQA ILELFDSQKY TRRTGENRVA WQLPRPV
//
