ID A0A1H6N7H6_9RHOB Unreviewed; 638 AA.
AC A0A1H6N7H6;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN04488075_2646 {ECO:0000313|EMBL:SEI07540.1};
OS Paracoccus alkenifer.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Rhodobacterales; Paracoccaceae; Paracoccus.
OX NCBI_TaxID=65735 {ECO:0000313|EMBL:SEI07540.1, ECO:0000313|Proteomes:UP000199125};
RN [1] {ECO:0000313|Proteomes:UP000199125}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11593 {ECO:0000313|Proteomes:UP000199125};
RA Varghese N., Submissions S.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FNXG01000005; SEI07540.1; -; Genomic_DNA.
DR RefSeq; WP_090848566.1; NZ_FNXG01000005.1.
DR AlphaFoldDB; A0A1H6N7H6; -.
DR STRING; 65735.SAMN04488075_2646; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000199125; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0004020; F:adenylylsulfate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SEI07540.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000199125}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 638 AA; 67886 MW; 0B93DC4E94250595 CRC64;
MIVGTAGHID HGKTALVRVL TGTDADRLAE EKTRGITIEL GFAYADLGDG GITGFVDVPG
HERFVHTMLA GAGGIDLALL VVAADDGVMP QTREHLAILD LLGVHRGVIA LSKADLADDA
RRAEVTAQIA ATLAGTGLNG APVLPVSSVT GEGIETLRLT LAQAAAATKA RALDRRFRLS
VDRSFALKGS GTVVTGTVLS GQVSVGDTVT VSPRGLAARV RAIHAQNRPV QTGIAGQRCA
LNLAGDGVSR DAIHRGDMVL DPALHAPSDR IDATLRVLGS EPRPIGTWFP ARLHSGAAEV
GARIVPLAEA LMPGAEGLVQ LVLDAPLAAS VGDRYILRDV SARRTIGGGV FVDLRAPARR
RRTPERMLQL AAAAQPDAEQ ALRAMLAAPP FMVDLGVFIR DRALGPDAAA RLAGAAVVLD
AGGSNVALSA DTHRQLVGAM LDTLARFHHE APEMQGPGRE KLRLALTPRL PKDAFAVLLS
ERIAAGDVVA EGAFLRLPTH IVRLSEADEA LYLRILPELS GEARFRPPRV RDMATAWDIP
ETDVRRVLRM AARQGRVDQI RHDHYFLRAT TAEMVGIIAE VQAEAPDGWV TAAAFRDRVQ
NGRKVAIEIL DFYDRQGVTL RRGDLRRINP HRADLYGG
//
