ID A0A1H9NYX5_9BACI Unreviewed; 375 AA.
AC A0A1H9NYX5;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 18-JUN-2025, entry version 30.
DE RecName: Full=Signal transduction histidine-protein kinase/phosphatase DegS {ECO:0000256|PIRNR:PIRNR003169};
DE EC=2.7.13.3 {ECO:0000256|PIRNR:PIRNR003169};
DE EC=3.1.3.- {ECO:0000256|PIRNR:PIRNR003169};
GN ORFNames=SAMN04487944_10419 {ECO:0000313|EMBL:SER41017.1};
OS Gracilibacillus ureilyticus.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Gracilibacillus.
OX NCBI_TaxID=531814 {ECO:0000313|EMBL:SER41017.1, ECO:0000313|Proteomes:UP000199687};
RN [1] {ECO:0000313|EMBL:SER41017.1, ECO:0000313|Proteomes:UP000199687}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 1.7727 {ECO:0000313|EMBL:SER41017.1,
RC ECO:0000313|Proteomes:UP000199687};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Member of the two-component regulatory system DegS/DegU,
CC which plays an important role in the transition growth phase.
CC {ECO:0000256|PIRNR:PIRNR003169}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085,
CC ECO:0000256|PIRNR:PIRNR003169};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR003169}.
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DR EMBL; FOGL01000004; SER41017.1; -; Genomic_DNA.
DR RefSeq; WP_089739921.1; NZ_FOGL01000004.1.
DR AlphaFoldDB; A0A1H9NYX5; -.
DR STRING; 531814.SAMN04487944_10419; -.
DR OrthoDB; 9781904at2; -.
DR Proteomes; UP000199687; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR008595; DegS.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR050482; Sensor_HK_TwoCompSys.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR InterPro; IPR016381; Sig_transdc_His_kinase_DegS.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF55; SENSOR HISTIDINE KINASE YDFH; 1.
DR Pfam; PF05384; DegS; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR PIRSF; PIRSF003169; STHK_DegS; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR003169};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR003169};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR003169};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR003169};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR003169};
KW Protein phosphatase {ECO:0000256|PIRNR:PIRNR003169};
KW Reference proteome {ECO:0000313|Proteomes:UP000199687};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR003169};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012,
KW ECO:0000256|PIRNR:PIRNR003169}.
FT DOMAIN 180..375
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 30..64
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 108..135
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 375 AA; 43743 MW; 0C7817B79FE040D5 CRC64;
METWDHDLDY IIQEMIETVK NSKDEVFHIS EESRKEYERI KTELEDLKEK VAVVIEEGDQ
LEINSKAARR KLSVVSRNFS VYSEDKIREA YDNAHKIQSE FIVKRDKEKA LRERRDDLEL
RLKSIEKMVE RAEGLMGKIS IVLNYLSEDF KHISDLLQNA QEKQAFGLQI IEAQEEERRK
LSREMHDGPA QMLANILLRS EIVDRTYRKG DTESAMKEMR NVRTLIRSSL QEVRRIIYDL
RPMALDDLGL VPTIKKYIAT LEEQHPNIHF QYRAKEERLA SQYEVALFRL IQESIQNAIK
HAKAERIDVK LEIVKDYVTA VIKDNGIGFD RSQKKDKSFG LIGMNERIDM LGGELDIVTK
VGEGTKIYIK IPLSS
//
