ID A0A1I0JW49_9ACTN Unreviewed; 325 AA.
AC A0A1I0JW49;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 18-JUN-2025, entry version 19.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:SEU15096.1};
GN ORFNames=SAMN05421811_106306 {ECO:0000313|EMBL:SEU15096.1};
OS Nonomuraea wenchangensis.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=568860 {ECO:0000313|EMBL:SEU15096.1, ECO:0000313|Proteomes:UP000199361};
RN [1] {ECO:0000313|EMBL:SEU15096.1, ECO:0000313|Proteomes:UP000199361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC 4.5598 {ECO:0000313|EMBL:SEU15096.1,
RC ECO:0000313|Proteomes:UP000199361};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; FOHX01000006; SEU15096.1; -; Genomic_DNA.
DR RefSeq; WP_091083627.1; NZ_FOHX01000006.1.
DR AlphaFoldDB; A0A1I0JW49; -.
DR STRING; 568860.SAMN05421811_106306; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000199361; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000199361}.
FT DOMAIN 3..169
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 325 AA; 34424 MW; DBD5A69FE2512DCB CRC64;
MKVAVLGAGA IGAYVGAALH RAGAEVHLIA RGEHLQAIRR AGVRVLSPRG DFTAHPHATD
DPAEVGPVDH VLLGLKANSY ASAGPMIAPL LHASTSIIAA QNGIPWWYFH RLKGPYEGYR
IESVDPGGAV TAALPLHRAV GCVVYAATEI ESPGVIRHLE GTRFSIGEPS GLLTDRCQTF
SEAAVEGGLK CPVERDLRRD VWIKLMGNIA FNPISALARA TMAGICRHDG ARELVVAMMR
ETVEVAGRVG CDPGVSIERR LRGAEKAGEH KTSTLQDLEK GKPLELDVLL AAVVELADLT
GADVPTLRAI HAVSDLLNAN LVRAV
//
