ID A0A1I0Q979_9BACT Unreviewed; 293 AA.
AC A0A1I0Q979;
DT 22-NOV-2017, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=hydroxymethylpyrimidine kinase {ECO:0000256|ARBA:ARBA00012135};
DE EC=2.7.1.49 {ECO:0000256|ARBA:ARBA00012135};
GN ORFNames=SAMN04487850_2268 {ECO:0000313|EMBL:SEW23573.1};
OS Prevotella aff. ruminicola Tc2-24.
OC Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
OC Prevotellaceae; Prevotella.
OX NCBI_TaxID=81582 {ECO:0000313|EMBL:SEW23573.1, ECO:0000313|Proteomes:UP000199373};
RN [1] {ECO:0000313|EMBL:SEW23573.1, ECO:0000313|Proteomes:UP000199373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TC2-24 {ECO:0000313|EMBL:SEW23573.1,
RC ECO:0000313|Proteomes:UP000199373};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
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DR EMBL; FOIQ01000006; SEW23573.1; -; Genomic_DNA.
DR RefSeq; WP_371113586.1; NZ_FOIQ01000006.1.
DR AlphaFoldDB; A0A1I0Q979; -.
DR Proteomes; UP000199373; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR020449; Tscrpt_reg_AraC-type_HTH.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR PRINTS; PR00032; HTHARAC.
DR SMART; SM00342; HTH_ARAC; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000313|EMBL:SEW23573.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000199373};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:SEW23573.1}.
FT DOMAIN 194..292
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
SQ SEQUENCE 293 AA; 32597 MW; 7569DC3FD8D4230C CRC64;
MMRPILTITG SDSTGGSGVQ ADIKTISELG GYALSAITSI TVQTTLGIQQ FYDIPATIVE
RQIDAVMNDF QPEVVKVGLI RRRDTLDVVV EALRKYRPRH VVLDAVVLSS RGDTLISHDM
QEAIRNELLP LCTLVVKKDE GSMHGLANRY ASAVAVFLSQ GAKSDEAKSK AKAYINTQVA
RAADLQGRSS ELYNEFLDAV TEHHRKASDV RFYADLLNVS SRYLAQVTRR ISGKAPKTII
DDYLTHEIER QLKSTDHTVQ ETAYLFGFSS QAHFTKFFKK QKGISPTAFR KQK
//
