ID A0A1I7S7D1_BURXY Unreviewed; 2467 AA.
AC A0A1I7S7D1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 08-OCT-2025, entry version 39.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=BXYJ_LOCUS1554 {ECO:0000313|EMBL:CAD5209675.1};
OS Bursaphelenchus xylophilus (Pinewood nematode worm) (Aphelenchoides
OS xylophilus).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Tylenchomorpha; Aphelenchoidea; Aphelenchoididae;
OC Bursaphelenchus.
OX NCBI_TaxID=6326 {ECO:0000313|Proteomes:UP000095284, ECO:0000313|WBParaSite:BXY_0892100.1};
RN [1] {ECO:0000313|WBParaSite:BXY_0892100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:CAD5209675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ka4C1 {ECO:0000313|EMBL:CAD5209675.1};
RA Kikuchi T.;
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048679};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047899,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
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DR EMBL; CAJFDI010000001; CAD5209675.1; -; Genomic_DNA.
DR EMBL; CAJFCV020000001; CAG9084939.1; -; Genomic_DNA.
DR SMR; A0A1I7S7D1; -.
DR WBParaSite; BXY_0892100.1; BXY_0892100.1; BXY_0892100.
DR eggNOG; KOG0891; Eukaryota.
DR OrthoDB; 2250022at2759; -.
DR Proteomes; UP000095284; Unplaced.
DR Proteomes; UP000582659; Unassembled WGS sequence.
DR Proteomes; UP000659654; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0031931; C:TORC1 complex; IEA:UniProtKB-ARBA.
DR GO; GO:0031932; C:TORC2 complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016242; P:negative regulation of macroautophagy; IEA:TreeGrafter.
DR GO; GO:0045727; P:positive regulation of translation; IEA:UniProtKB-ARBA.
DR GO; GO:0038202; P:TORC1 signaling; IEA:TreeGrafter.
DR CDD; cd05169; PIKKc_TOR; 1.
DR FunFam; 1.10.1070.11:FF:000040; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.20.120.150:FF:000001; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 3.30.1010.10:FF:000006; Serine/threonine-protein kinase TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR057564; HEAT_ATR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF23593; HEAT_ATR; 1.
DR Pfam; PF11865; mTOR_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000659654};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1320..1941
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2115..2434
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2435..2467
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1178..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2467 AA; 282152 MW; 6BC005BC74EB1540 CRC64;
MPHELLGQLQ KVSSQDHGMA ELPEQLERIQ KHLSVLRHSP ELRQRCFTIL TYGEKKVLDY
LNSQDKLDRQ AAVILMVCFV EVNVGEETNK VLVFANALLK TIECPDESVS FLASRALIYL
IHTSKAYSLE MVDIAFSRCA DWFDQGKRSC NKMAGSILYR DLALFTSTHF FQSARIFFDH
IFYAIKDSKI NVRVVGADAL HAALTVTSQR ETKQKNDWYK RLFEEACLKQ DTLSKDDSLH
ASLLLLNELL RVANATAEQR RLEIEGNQQR DVTGTVVGQN PVTWLFQGIH RPAVESHTAN
LLISENYFGE IIRKCMEASS TKSKECQLLL LEIFPRIVCF RTSYDLPLDH IVEWTLGMLS
KQPQAFLSFG LYSMERPQEL NPKTSKFISM IAAQMNQNPL KRRAVAPNFF KALCLLVRSQ
KQTVCEDIRR NLSLILSTGL SKNLTELCHH TIANIPSLKT ELLDGLMDQL YQLLMGLSPP
SKLAPPTDPP IPHGPVSITN VALTELALET LGNFDFQRHT LQMFMRYIAL GYLVCDVVEI
RLAAARCCIQ IVKPFIRVFD MVESTQKLEV YELIRNVLDC LIKVTVTDQV VQVRLSVLEY
FATVEMDFLY HLSQKESLLS LFMTLYDEDF RVQEKAVELL AKLSNLNPAL IFPKLRKVVK
ETIYNLSVSR ISKNEVHAAR IVCQLGRCAP NFVSTFMNSL LLALVPHLRV DGKSSEVTVN
VLNAISELAL IGGLDIVRAT NKLIPSFVSY LQDSTSLNRR EAALRALGNL CQSSAYVVEP
YKDHPQLLDI LLRLLKTELS SSMRRLTMKV LGIVGALDPY THKVFLGTVH SSASKSLALS
LPLNSAKGRY LPDEADIIQW ISYEKCTLEE FYPTLAVSNL VKMFDDYSVS SLYRDVVQAI
MLLFSNLGSR LGDYVDKVIP KLIRVTQECK PELREFFLSQ FAQLTALLGH QIKPYINDIF
SIIKVAWQWD QPSLKGKAIF LLEQVGRAME YHFMPYVGDL CPYLLAVVET DSTKDKSLTL
SALSCVRSLS ICLGTYIHVV LPPVLEVLNN KAVPEKIRIF ALDTVITLAR DHSLGERATV
ILQAWLKCIS VKYLQEKLMA LLSIVLVQMW VQFTVYRDSV DAALNKYKIE QSLRSDYDDL
VIQMINAPKN PPVSYLLPQV GRRFPTGAFP GNNYAQAAGS GGVPRTINQS SSRMSLKDKA
PRNIEHLKRF WSAPVVVSRD EWLQWLATLR TQVLRHSPSF ALRICAPLAE LYEPLAKELF
NAAFMSVWTE LTESDQDEVT AQFVDVITIC PYSEPIQAVL NLAEFMDHSE KGPLPIKYNL
LCECAENTRA YAKALRYKEL HILSSEVSTP SADDCQGLIG YANKLNLEEA AVGVVKYAEK
KEMEISAKWY EKLGEWEKAL DLYKEATHKE HGNETRIDQM RCLEALGYWT ELTEFSDATL
ESLEGDTRKI RSEQRRKFHQ MSARGCWASG NYEKMAMYVD LISENYHEGA FLRAVLAIKK
NRFPEAYQCI TKVRDMLDSE LTAMASESYE RAYGAVLMAQ QLTELEEAIE YKLIPERRTR
IAILWSRRLQ GCRKNVEHWQ RIMMARSLVL SQNELRPMWV KFASLCRREG RMATSRRVFC
SLLDLSENSP LDQVKIPVDK PFLSLALCKQ VWADGNKNTA YNNVKSLAST LHRLIETNSG
MLSKEHLENM THITAKCYLK LGDWNMELQP LFANSLPPSR TSRHPHSQRT EITVQYSHSQ
AEINNFEQST KITLQHYMNA THFYPSWYKA WHKLGTVYYN LVMTERQLMF GSPDGSMYTR
RDGVCDDYPE LEQSTKPYRG SSSPIDHKSI LQNPQMITSY ALKAVQCFLK AIQLAEGSRL
EDTLRLLMLL FDHGDKSEIF DYLRDAVKVV PVEIWLEVVP QLMSRMDSKK NVGLLVKQVV
IDIAKTHPQA IVYALTAAKK SKNTQRCKVA ADILQLMAED RPVFVEQACL LNDELIRCAI
LWHEMWHGTL EEASRLYFQE KNFQLMMDAL RPLHQKIEAG HTTMKEESFN QTYYKELRDA
YDHCLAFERT GNQKEITQAW DLYYKVFKKI SSQLRQMTAL ELSYISPKLL QVYNLEISVP
GTYDPSSDVV TIASVLPHLE VIMSKQRPRK VSMRGNDGKE YSFLLKGHED PRQDERIMQL
FGLINSLIIR DADTSRRNLS IQRYSIIALS QSSGLIGWVP NCDTLHTLIR DYREKHHITI
SEEHTRMQKL VIDIEKLTLM QKVEVFDEAL RSTSGDDLRQ TLWMKSPNSE VWFDRRTNYT
RSMACMSMVG YVLGLGDRHP SNLMLDRLSG KIVHIDFGDC FEVAMKRVKY PEKIPFRLTR
MLVRAMEVTG IEGNFRLTCE KVLNLLRNNN DSILAVLEAF VYDPVMNWRL TEPSNRRDNN
YLEVEQEEQQ LTGSHTEAIS RVKAKLTGRD FNALEEITVA EQVSRLIEQA TLYDNLCQCY
IGWCPFW
//
