ID A0A1I7V9L6_LOALO Unreviewed; 719 AA.
AC A0A1I7V9L6; A0A1S0UDJ9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 10-JUN-2026, entry version 41.
DE SubName: Full=Rho GTPase-activating protein syd-1 {ECO:0000313|WBParaSite:EN70_11363};
GN Name=LOAG_18941 {ECO:0000313|WBParaSite:EN70_11363};
OS Loa loa (Eye worm) (Filaria loa).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11363};
RN [1] {ECO:0000313|WBParaSite:EN70_11363}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
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DR RefSeq; XP_020304600.1; XM_020451603.1.
DR STRING; 7209.A0A1I7V9L6; -.
DR GeneID; 9951538; -.
DR KEGG; loa:LOAG_18941; -.
DR WBParaSite; EN70_11363; EN70_11363; EN70_11363.
DR CTD; 9951538; -.
DR eggNOG; KOG1452; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR OMA; SAWHPID; -.
DR OrthoDB; 120383at2759; -.
DR Proteomes; UP000095285; Unassembled WGS sequence.
DR GO; GO:0043005; C:neuron projection; IEA:GOC.
DR GO; GO:0042734; C:presynaptic membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:EnsemblMetazoa.
DR GO; GO:0008088; P:axo-dendritic transport; IEA:EnsemblMetazoa.
DR GO; GO:0016477; P:cell migration; IEA:TreeGrafter.
DR GO; GO:0030030; P:cell projection organization; IEA:EnsemblMetazoa.
DR GO; GO:0008104; P:intracellular protein localization; IEA:EnsemblMetazoa.
DR GO; GO:0040011; P:locomotion; IEA:EnsemblMetazoa.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:TreeGrafter.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR052118; Rho-GAP_regulator.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR057459; SYDE1/2_C2.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF25336; C2_SYDE; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00172}; Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT DOMAIN 322..447
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 472..719
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 480..690
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..704
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 719 AA; 80162 MW; ED5B54D572D900FD CRC64;
MAKRCSQPSS ASSSSVTATG VSSMMTISPR QHFTGQQSSR HLNSQTEKLE ETVSRTARIP
PPKLLPSTVR RADSFTTNAQ LPIQMLPSYT YSMPRSLTQR PVPLQSFPGP STAPDYLPAS
SSYGAFPGSF GLSQFHVPSS GTSRPLPINQ RSLSDVAGYA MHHSLCSPSG AMDPRYMLRG
QSAWHPIDSS IRSNSLPRRR AISGTAPRSV KWRNDVIDGA NARMRFGSSN VSGQYGRTID
DIFSAQEYRN WACFDTGIRP EERQSRWSHT YGEKPGASIR SSSLPSRAML TATNRFSLGH
ERGDVLDRLH VSPLMNRRVP LRIAGPGFDV DTPLDVTSLT GILIVQIIEG RGLRMPEKQK
AFTEEMYCVL EVNETHRART GVSTAEQKFR WRETFEIDVQ HATHTNFFVY SWHPRYRHKL
CHKGSLKLLE AFVVDRLNGN RMFALNLEPK GQLIVKIAFH SVAVAFRRIV NCRYDGLFGI
PLQRLVAREG RETPLVLSRL LQEIEHRGVD YSGLYILCGS LEKKRMLREE LEINVERARL
NVEAVPDTNV LACLVKDFLR ELPEPLISTS IYNMIVEAFS VALPNDPRGN RRLLLRVIDC
LPAANKNTLI QIMDHLKMVM SSEQHNGITA ARLTDIFGCL LFCSCNGTME NSSTEDSSGI
YQSKTIINPL DTDQAARTLR SLIDIWPSRV NGSESSSSGS VSNSTDVTNT INPVSESQC
//
