ID   A0A1I7VAU6_LOALO        Unreviewed;       351 AA.
AC   A0A1I7VAU6; A0A1S0TR12;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-OCT-2025, entry version 40.
DE   SubName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000313|WBParaSite:EN70_11775, ECO:0000313|WBParaSite:EN70_11776};
GN   ORFNames=LOAG_10131 {ECO:0000313|EMBL:EFO18365.1,
GN   ECO:0000313|WBParaSite:EN70_11775, ECO:0000313|WBParaSite:EN70_11776};
OS   Loa loa (Eye worm) (Filaria loa).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Loa.
OX   NCBI_TaxID=7209 {ECO:0000313|Proteomes:UP000095285, ECO:0000313|WBParaSite:EN70_11776};
RN   [1] {ECO:0000313|EMBL:EFO18365.1, ECO:0000313|Proteomes:UP000095285}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Henn M.R.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Loa loa.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:EN70_11775, ECO:0000313|WBParaSite:EN70_11776}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriolar satellite
CC       {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family.
CC       {ECO:0000256|ARBA:ARBA00005822}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JH712346; EFO18365.1; -; Genomic_DNA.
DR   RefSeq; XP_003145706.1; XM_003145658.2.
DR   AlphaFoldDB; A0A1I7VAU6; -.
DR   FunCoup; A0A1I7VAU6; 347.
DR   STRING; 7209.A0A1I7VAU6; -.
DR   GeneID; 9947571; -.
DR   KEGG; loa:LOAG_10131; -.
DR   WBParaSite; EN70_11775; EN70_11775; EN70_11775.
DR   WBParaSite; EN70_11776; EN70_11776; EN70_11776.
DR   CTD; 9947571; -.
DR   eggNOG; ENOG502QR2Z; Eukaryota.
DR   OMA; PNFGIQY; -.
DR   OrthoDB; 10261999at2759; -.
DR   Proteomes; UP000095285; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; IEA:EnsemblMetazoa.
DR   GO; GO:0034464; C:BBSome; IEA:InterPro.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:EnsemblMetazoa.
DR   GO; GO:0097546; C:ciliary base; IEA:EnsemblMetazoa.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097730; C:non-motile cilium; IEA:EnsemblMetazoa.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:TreeGrafter.
DR   GO; GO:0060271; P:cilium assembly; IEA:TreeGrafter.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095285}.
FT   DOMAIN          33..87
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          164..218
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   351 AA;  40049 MW;  E6F47D8E53FB80DD CRC64;
     MNSKLQIPSI AIWQDRDIRF DVNPRLLHLI AGENLVDRID DVEDTKGNCG DKGVLRITNL
     RLTWHAIAIP RINLSLGYNT ISGVTTKMTK SRLRGQAESL YLLAHHANAR YEFIFTCINP
     SQTKLFTTVI AIHRAYETSK LYREIKMRGA LVNDEQHLRI LPEEQQCDRY DGVWNLGNDQ
     GTLGVMILTN IRIVWFATTN IRYNVSIPYL QLQNCRIRHS RFGLALVIET SAVNREYVLG
     FRIDPEERLK NAHRTICALQ SAYITKPIFG VQYIREKPGT PQAVGDIMKL VDEDVELDDR
     PLRSDAYAVY FSDGVVSGQV RPPVYSPELG VAIEQLKPGF TLTDLWNIHV E
//