ID A0A1I8MSU0_MUSDO Unreviewed; 398 AA.
AC A0A1I8MSU0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 28-JAN-2026, entry version 45.
DE RecName: Full=Proteasomal ubiquitin receptor ADRM1 homolog {ECO:0000256|ARBA:ARBA00070663};
GN Name=101897204 {ECO:0000313|EnsemblMetazoa:MDOA008100-PE};
GN Synonyms=LOC101897204 {ECO:0000313|RefSeq:XP_005175306.1,
GN ECO:0000313|RefSeq:XP_011291231.1, ECO:0000313|RefSeq:XP_011291236.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA008100-PE};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA008100-PE}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA008100-PE};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005175306.1, ECO:0000313|RefSeq:XP_011291231.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005175306.1,
RC ECO:0000313|RefSeq:XP_011291231.1};
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- FUNCTION: May function as a proteasomal ubiquitin receptor. May promote
CC the deubiquitinating activity associated with the 26S proteasome.
CC {ECO:0000256|ARBA:ARBA00054744}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ADRM1 family.
CC {ECO:0000256|ARBA:ARBA00009216}.
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DR RefSeq; XP_005175306.1; XM_005175249.3.
DR RefSeq; XP_011291231.1; XM_011292929.2.
DR RefSeq; XP_011291236.1; XM_011292934.2.
DR AlphaFoldDB; A0A1I8MSU0; -.
DR STRING; 7370.A0A1I8MSU0; -.
DR EnsemblMetazoa; MDOA008100-RA; MDOA008100-PA; MDOA008100.
DR EnsemblMetazoa; MDOA008100-RC; MDOA008100-PC; MDOA008100.
DR EnsemblMetazoa; MDOA008100-RD; MDOA008100-PD; MDOA008100.
DR EnsemblMetazoa; MDOA008100-RE; MDOA008100-PE; MDOA008100.
DR KEGG; mde:101897204; -.
DR VEuPathDB; VectorBase:MDOA008100; -.
DR VEuPathDB; VectorBase:MDOMA2_005612; -.
DR eggNOG; KOG3037; Eukaryota.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP001652621; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR FunFam; 1.10.2020.20:FF:000003; Proteasomal ubiquitin receptor ADRM1 homolog; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Receptor {ECO:0000313|RefSeq:XP_005175306.1,
KW ECO:0000313|RefSeq:XP_011291231.1};
KW Reference proteome {ECO:0000313|Proteomes:UP001652621}.
FT DOMAIN 12..125
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 255..369
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 166..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..185
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..236
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 42581 MW; 6880FE3F91530C87 CRC64;
MFGRQSLGSG SSNGSNLVEF RAGRMNFIGK MVHPDTRKGL VYLTQSEDGL MHFCWKDRTT
GKVEDDLIVF PDDFEFKRVE QCKTGRVYVL KFKSSSRRMF FWMQEPKTDK DEEHCRRVNE
LMNNPPSASR GGGQDGGDLQ YMLNNMSQQQ LMQLFGGVGQ MGGLSSLLGS MNTRTPSSNR
NSSSSAAGLV TPENSSAPRT PSAPKAKGSK SSSSGTGNTS TEGGAAATGG KKSSNSVTPT
NAFQSFLSNL SPEAGAGRSL NIDLSSALAG SEAINELISD PERVNTLSVH LPETEDADEN
KKQQIKETIA SPQFQQALSL FSNALQSAQL GPVVSQFELT PEAVAAAYSG NLEDFVKALE
KALPAGATMS SSPVSSKGKD TAEVKKDETT DQAAEKKE
//
