ID A0A1I8N2Y0_MUSDO Unreviewed; 1141 AA.
AC A0A1I8N2Y0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 18-JUN-2025, entry version 49.
DE SubName: Full=Transient-receptor-potential-like protein {ECO:0000313|RefSeq:XP_011295208.1};
GN Name=101899557 {ECO:0000313|EnsemblMetazoa:MDOA010974-PB};
GN Synonyms=LOC101899557 {ECO:0000313|RefSeq:XP_011295208.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA010974-PB};
RN [1] {ECO:0000313|RefSeq:XP_011295208.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26156588;
RA Li D., Liang Y., Wang X., Wang L., Qi M., Yu Y., Luan Y.;
RT "Transcriptomic Analysis of Musca domestica to Reveal Key Genes of the
RT Prophenoloxidase-Activating System.";
RL G3 (Bethesda) 5:1827-1841(2015).
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA010974-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010974-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_011295208.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, rhabdomere membrane
CC {ECO:0000256|ARBA:ARBA00043946}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00043946}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. {ECO:0000256|ARBA:ARBA00060916}.
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DR RefSeq; XP_011295208.1; XM_011296906.2.
DR STRING; 7370.A0A1I8N2Y0; -.
DR EnsemblMetazoa; MDOA010974-RB; MDOA010974-PB; MDOA010974.
DR VEuPathDB; VectorBase:MDOA010974; -.
DR VEuPathDB; VectorBase:MDOMA2_010359; -.
DR eggNOG; KOG3609; Eukaryota.
DR OrthoDB; 2373987at2759; -.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0034703; C:cation channel complex; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0015279; F:store-operated calcium channel activity; IEA:TreeGrafter.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:TreeGrafter.
DR FunFam; 1.25.40.20:FF:000221; Transient receptor potential-gamma protein; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR PANTHER; PTHR10117:SF47; TRANSIENT-RECEPTOR-POTENTIAL-LIKE PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00023305};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 152..184
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 187..249
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 980..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 901..958
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 995..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1082
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1141 AA; 129965 MW; 5918F0980FB14B5B CRC64;
MVLLNRKDQK GVASHTVGAG STETLKHGCL PIGLPQPLEM EEKKFLLAVE RGDIANVRRI
LQKAHRKHHI NINCMDPLGR RALTLAIDNE NLEMVELLVI MGVETKDALL HAINAEFVEA
VELLLEHEEL IYKEGDLYSW QKVDINTAMF PPDITPLILA AHKNNFEILK ILLDRGAAVP
VPHDIRCGCD ECVRMSIEDS LRHSLSRVNI YRALSSPSLI CLTSHDPIIT SFQLSWDLRN
LSITEQESKS EYVELRRQCQ QFAVDLLDQT RTSNELAIIL NYDPDMSTYQ PGDRMSLSRL
TQAVYYKQKK FVAHSNIQQL LSAIWYEGLP GFRRKSLLEK MICIAQVAVL FPIYCMVYMV
APNCKTGVLM RKPFMKFLIH ASSYLFFLFI LILVSQRADE DVIRILGSDR MKQQLLEEKM
RQRGRGPTKL ELLVVLYVFG FMWEEVQEIF NVGMKCYLRN MWNFIDFLRN SLYISVMCMR
TFAYIQQSRE ISKDPKMAFV PREQWDDFDP QLIAEGLFAA ANVFSALKLV HMFSINPHLG
PLQISLGRMV IDIVKFFFIY SLVLFAFACG LNQLLWYFAD LEKSKCYVLP NGEADWAGHS
DSCMKWRRFG NLFESSQSLF WASFGMVGLE DFELTGIKSY TRFWGLLMFG SYSVINVIVL
LNLLIAMMSN SYAMIDEHSD TEWKFARTKL WMSYFEDSPT LPPPFNILPS VKWLIRLFRK
SSKEIDRKRS KKRHAKEQDN AYENIMRSLV WRYVAAQHRK FEDNPVTEDD INEVKSEIST
MRYEMLDIFE SSGMDVTSAA KKEKPCRAKK TKVWERRLMK GFQLGPVENV NDEKAPNNGN
VNGAGDMNEI KIEKEASRPL NETPKQKFQR VARQVAAQST AHKWTVVIQG TLKNSQIGRS
NQDSAKNLQQ LNKAIEEAKK LILHTPGHVS GRDSPIAVEF EDEKAETLLE LLNQISEELS
SESSSGNRPN VEEVKKKFLQ YQKTPPGTEA KSILKDSQPS ARTKSPASKT VTTRSQTAPE
IQRNKNLAPN QGPPVSHKSR KPENVAAGSS QKSKKIEELT LSAGKLSSMK KAAPPAPGGA
KPQDGSSRTP FSVELNRPGH RHGYDNRTLV STANMDFNVV DLDDYDNGMT DDISQISGEY
Q
//
