ID A0A1J1HEC8_PLARL Unreviewed; 1273 AA.
AC A0A1J1HEC8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 28-JAN-2026, entry version 38.
DE RecName: Full=P-type sodium-transporting ATPase4 {ECO:0000256|ARBA:ARBA00067200};
DE EC=7.2.2.3 {ECO:0000256|ARBA:ARBA00035029};
GN Name=ATP4 {ECO:0000313|EMBL:CRH03767.1};
GN ORFNames=PRELSG_1312600 {ECO:0000313|EMBL:CRH03767.1};
OS Plasmodium relictum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Haemamoeba).
OX NCBI_TaxID=85471 {ECO:0000313|EMBL:CRH03767.1, ECO:0000313|Proteomes:UP000220158};
RN [1] {ECO:0000313|EMBL:CRH03767.1, ECO:0000313|Proteomes:UP000220158}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SGS1 {ECO:0000313|EMBL:CRH03767.1,
RC ECO:0000313|Proteomes:UP000220158};
RG Pathogen Informatics;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:14633, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.3;
CC Evidence={ECO:0000256|ARBA:ARBA00049499};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14634;
CC Evidence={ECO:0000256|ARBA:ARBA00049499};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. {ECO:0000256|ARBA:ARBA00038148}.
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DR EMBL; LN835308; CRH03767.1; -; Genomic_DNA.
DR RefSeq; XP_028535774.1; XM_028678649.1.
DR AlphaFoldDB; A0A1J1HEC8; -.
DR GeneID; 39738059; -.
DR KEGG; prel:PRELSG_1312600; -.
DR VEuPathDB; PlasmoDB:PRELSG_1312600; -.
DR OMA; QEVHLGH; -.
DR OrthoDB; 116380at2759; -.
DR Proteomes; UP000220158; Chromosome 13.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:TreeGrafter.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR FunFam; 3.40.50.1000:FF:000001; Phospholipid-transporting ATPase IC; 1.
DR FunFam; 3.40.50.1000:FF:000083; Sodium/potassium-transporting ATPase subunit alpha; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 2.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR43294:SF20; P-TYPE ATPASE; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000220158};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..953
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1005..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1238..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..203
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 141488 MW; 9044F3DFA32B99AE CRC64;
MNSDNPHINL SEKGKLDEHV NGEKSNKKEI NEKTKNNNSI DVTEEKDLND KTNIEQKYLE
NKENDTDNGN RGLLNYADNL EDEIIGRLSK SQQSPEEIIE NAKIEDSDAY YMALQKAEEE
CKSTGNNYYA TESIENMCKE FGLEDINLGL DSKQVEINRE KYGENFIEKE QVVPIWKIFL
SQYWSPVVIL LLIAAVASLS LNEIVEGIAI ISIVTLNACL ATYMEKSSGD AIAKLAEMAS
PQCTVLRNGQ KVVIPSREVV VGDVVVISTG DSISADLRLF EVIELKTNES LLTGESEDIK
KTLVAIDPTT PFATNLCFAT TSVTNGCGKG IVISTGLETQ VGKIASQLKR TSKGSKLTPL
QVALNKLGGL IGLIAIIVLV GIIVLAVLIK YRDPAHSDKD PTFVIIIIGV GFAVSSIPEG
LPMVVTITLS AGAKDMVRKN ANVRKLPAVE TLGCCSVICS DKTGTLTEGK MTAINAVTIC
KNSSLSDDNY NLTKTFDFYP TKGFEPYGGL FDSKELTNEK KKSIVIAKNQ NISYDTVLYN
YGNALNKSPT VDKARSLMLA AYLNSYDTTL ARDSKTSKWS IQGNMSEGPI VVAAAKVGYN
FNNNTSNNSY LKEYIRLDNL EVTFNSSRKM KITFYKLRKE NIFENIYLEN FNKTYTHIAI
IKGAPDKLLD KSTHLLKETK KKTYISWEDK ITEEEKNILT RKNLELSQKA LRVLAVCIKP
LTEEDIEYLK KLSDAEERLN YVNYDKSGGF IPLGYIASFD PPRPGVKEAI QTCREAQVKV
IMITGDQKPT AIAIGKLIGL INEKLDEKEK NYSEAIECSE LHINKNPNEP VLPNTQLDEF
TDKILIYSRA QPEDKITIVQ SLKRKGYLVA MTGDGVNDAP ALKAADIGVA MGINGTEVAK
GASEMILIDD NFCTVVSAID VGRTIYSNIQ KFVCFLLGTN IGEIIYLSIA IAAQMPFPLE
ALQILFLNLM TDGCPAVALS KEPPNDDNMK VPPRPKKQPI MTKTWWFYGI IPHTIFEALC
VLLSLAISLY LCTGSFTLNG INDSCKTANI PDINIGTKFH EYKYFCSTYE YRISSKYVGW
VTNVNFWDPS KNATVTFLGA AKGRIKNITP KSKEIHPNIR SIMKNGCSGD VKEDSLGWCM
PSDKARATGK DDDIPGILKK GYEDIAARGS KRGRTMAFIS AVWCEMLRAY TVRSWKPFYS
VFNRNMWMHL ACSISATLTF LSTCIPGITS VLNTTCLLWW QYILAILWAF LNLVLDEVIP
KVIYRRKYMT IKN
//
