ID A0A1J4KGA3_9EUKA Unreviewed; 713 AA.
AC A0A1J4KGA3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 02-APR-2025, entry version 28.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=TRFO_22590 {ECO:0000313|EMBL:OHT08828.1};
OS Tritrichomonas foetus.
OC Eukaryota; Metamonada; Parabasalia; Tritrichomonadida; Tritrichomonadidae;
OC Tritrichomonas.
OX NCBI_TaxID=1144522 {ECO:0000313|EMBL:OHT08828.1, ECO:0000313|Proteomes:UP000179807};
RN [1] {ECO:0000313|Proteomes:UP000179807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K {ECO:0000313|Proteomes:UP000179807};
RA Benchimol M., Almeida L.G., Vasconcelos A.T., Perreira-Neves A., Rosa I.A.,
RA Tasca T., Bogo M.R., de Souza W.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT08828.1}.
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DR EMBL; MLAK01000657; OHT08828.1; -; Genomic_DNA.
DR RefSeq; XP_068361964.1; XM_068502643.1.
DR AlphaFoldDB; A0A1J4KGA3; -.
DR GeneID; 94837347; -.
DR VEuPathDB; TrichDB:TRFO_22590; -.
DR OrthoDB; 10009520at2759; -.
DR Proteomes; UP000179807; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20335; BRcat_RBR; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000179807};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 197..533
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT COILED 378..439
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 713 AA; 84715 MW; 10F8E5FC689E8EF0 CRC64;
MNNYQNFDFI QEKGIQISDL LFSQTTLTDW VQSVRDEYNY SCEFPEETFS KLNEITKSDK
DLNGALRGIC FDPDCPENSI ILFQYIFFPE SKEDHQDENY EEEQNENDFD IDDSFSQEIK
LTMTSEELEM KQNDQIENLS NILEISKDVS LLLLKRYNWS TDRIVSDFCD NHQEILNLLH
IKEEDLNNSL SFRVIKGNFE CGICFCECDE IYELYCAHKF CRECWCDYIK SSVEKGSSTI
HCMEENCDAE IMPSDVSRLC GEEIGTAYKK YILDEQVNSN NQLLHCTAPG CKNVLTLESV
GICNIATCPC GKRICWKCKE DVHVPMKCGQ MKEWNDCAES MLCLVREQRK WENREKKIME
WRRNHIGEIQ SFYEEKIEKS KQEKVEKDEN ERTEIERLIA QFKSEPNNQE IKEKIEKKER
EHKINEQERQ KEIESLENEL HNFLIGIRDS NYSDFYMRNV RESEELREWS KREHTTEELL
DHITRKCPKC GRRIEKDGGC NFMQCSQCSF QFCWVCGSDW STHGDHFICN KFDGTVLNEV
DDEDIGFEDN EEIGDLDPKD FLYKKQSLPP MNEENITSFN KFNHYFKRYM MHIKAHKLEL
KYRDSYRQNL LQDFLHEMSE RTANEFIHRI FKAIDIARST LTFSYPAAYL WKNGSRGLIF
FETYQSNLEI AMEKLVGMVE RNLDDNTSHF EHFTEMLEKY TNIMLSETDK YMY
//
