ID A0A1J5NTJ4_NEOTH Unreviewed; 634 AA.
AC A0A1J5NTJ4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 28-JAN-2026, entry version 34.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:OIQ59103.1};
GN ORFNames=MOTE_15200 {ECO:0000313|EMBL:OIQ59103.1};
OS Neomoorella thermoacetica (Clostridium thermoaceticum).
OC Bacteria; Bacillati; Bacillota; Clostridia; Neomoorellales;
OC Neomoorellaceae; Neomoorella.
OX NCBI_TaxID=1525 {ECO:0000313|EMBL:OIQ59103.1, ECO:0000313|Proteomes:UP000182811};
RN [1] {ECO:0000313|EMBL:OIQ59103.1, ECO:0000313|Proteomes:UP000182811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21394 {ECO:0000313|EMBL:OIQ59103.1,
RC ECO:0000313|Proteomes:UP000182811};
RA Poehlein A., Bengelsdorf F.R., Esser C., Duerre P., Daniel R.;
RT "Genome-based comparison of Moorella thermoacetic strains.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OIQ59103.1}.
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DR EMBL; MDDC01000010; OIQ59103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1J5NTJ4; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000182811; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015189; Elong_fac_SelB-wing-hlx_typ-1.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09105; WHD_1st_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 4.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:OIQ59103.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 634 AA; 70757 MW; 98B6C2DE15F63FDE CRC64;
MDYIIVGTAG HVDHGKTVLV KALTGVDTDR LKEEKERGIS IELGFAPLTL PSGRQLGLVD
VPGHERFIRQ MLAGVGGMDL VMLVVAADEG VMPQTREHLA IIDLLQIKKG IVVVTKIDLV
EADWLELVRE EVRQAVNGTV LEDAPLVEVS ALTGEGIAEL REQLDALAAV TPPRPAAGRV
RLPVDRVFSV TGFGTVVTGT LWSGTIKVGD ELEVQPEGLK TRARNLQVHG RTVKEARAGQ
RVAVNLAGIE TEAVHRGSSL LEPGFLSPTY RLDASFKLLD GARPLANRHR VHFYLGTTEA
LGRVILLDRD ELNGGEEALV QLLMEKPVVA SREDRFILRS YSPMETIGGG IIIDPAPPRH
RRFRPEVLDS LRRRLEGSPE KILAQVIQEH REGLDWHEAA SRASLSLEET RKLLQAMAAD
GQVTLLRVEN DLYAISTGLY QAWWQVVARA LEEFHRHYPL RPGLAREELR SRYFSRLPAR
VYQALLEEWA REGRLQLAAN TIALAGFTPS FNETQKKLLK ELEEKYRASR WQPPSFKEVA
ASFNLDQVEL EELLHYLVRE GALVKINDEF YWHRQALGEA REVIKNLAST GPFGLAEARD
ALGSSRKYVL PLLEYLDKVK FTRRLGDKRV VVGN
//
