ID A0A1L8G1C3_XENLA Unreviewed; 537 AA.
AC A0A1L8G1C3;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 28-JAN-2026, entry version 39.
DE SubName: Full=suppressor of cytokine signaling 5 {ECO:0000313|RefSeq:XP_018120528.1, ECO:0000313|RefSeq:XP_018120529.1};
GN Name=socs5.S {ECO:0000313|RefSeq:XP_018120528.1,
GN ECO:0000313|RefSeq:XP_018120529.1, ECO:0000313|RefSeq:XP_041420218.1,
GN ECO:0000313|Xenbase:XB-GENE-17335412};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|RefSeq:XP_018120529.1};
RN [1] {ECO:0000313|RefSeq:XP_018120528.1, ECO:0000313|RefSeq:XP_018120529.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018120528.1,
RC ECO:0000313|RefSeq:XP_018120529.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018120528.1,
RC ECO:0000313|RefSeq:XP_018120529.1};
RG RefSeq;
RL Submitted (APR-2022) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_018120528.1; XM_018265039.2.
DR RefSeq; XP_018120529.1; XM_018265040.2.
DR RefSeq; XP_041420218.1; XM_041564284.1.
DR AlphaFoldDB; A0A1L8G1C3; -.
DR STRING; 8355.A0A1L8G1C3; -.
DR PaxDb; 8355-A0A1L8G1C3; -.
DR GeneID; 108717737; -.
DR KEGG; xla:108717737; -.
DR AGR; Xenbase:XB-GENE-17335412; -.
DR CTD; 108717737; -.
DR Xenbase; XB-GENE-17335412; socs5.S.
DR OMA; CQNLFNH; -.
DR OrthoDB; 8820570at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000186698; Chromosome 5S.
DR Bgee; 108717737; Expressed in blastula and 19 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 382..477
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 472..521
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 115..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 61424 MW; 3ED0E03A48425587 CRC64;
MDKVEKMWNT FKYRCQNLFS HDDDANQNDV VDVNANRCLR GIDKIENASG QSAMLSIGPL
QQNITSGLNL SPSGGSSRRN QNCVSEMPQL VEISVEKDAD LGLSAGTRLA RRDSYTRHAP
WSGKKKHSCS TKTQNSFDTD KKICRTRSGL QRRERRHGAS SVHDMETIGS RAVGSRSLRQ
RLNETVGFCF PIRTYNRPSK PLFTNKRKIQ LSELMLEKCP FPPGSDLAQK WHLIKQHTAP
VSPHSSFLET FDQSLISTED EEERLRERRR LSIEEGVDPP PNAQIHTFEA TAQVNPVYKL
GPKLAPGMAD LSGDVNAVCQ GGCESEEDTT TLCLQSRRQK QRQFSGDSHT QINKQGAWKV
HTQIDYIHCL VPDLIEIISN PCYWGVMDRY EAEALLEGRP EGTFLLRDSA QEDYLFSVSF
RRYNRSLHAR IEQWNHNFSF DAHDPCVFHS STVTGLLEHY KDPSSCMFFE PLLTVPLNRT
FPFSLQYICR AVICRSTTYD GIDLLRLPSM LQDFLKEYHY KQKVRVRWLE REPVKAK
//
