ID A0A1L8HPJ6_XENLA Unreviewed; 1044 AA.
AC A0A1L8HPJ6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 10-JUN-2026, entry version 56.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=rnf31.S {ECO:0000313|RefSeq:XP_018095564.1,
GN ECO:0000313|Xenbase:XB-GENE-968737};
GN Synonyms=rnf31 {ECO:0000313|RefSeq:XP_018095564.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|Proteomes:UP000186698, ECO:0000313|RefSeq:XP_018095564.1};
RN [1] {ECO:0000313|RefSeq:XP_018095564.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018095564.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018095564.1};
RG RefSeq;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. {ECO:0000256|ARBA:ARBA00008278}.
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DR RefSeq; XP_018095564.1; XM_018240075.2.
DR AlphaFoldDB; A0A1L8HPJ6; -.
DR GeneID; 779341; -.
DR AGR; Xenbase:XB-GENE-968737; -.
DR CTD; 779341; -.
DR Xenbase; XB-GENE-968737; rnf31.S.
DR OrthoDB; 9978677at2759; -.
DR Proteomes; UP000186698; Chromosome 1S.
DR Bgee; 779341; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0036435; F:K48-linked polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:1990450; F:linear polyubiquitin binding; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0097039; P:protein linear polyubiquitination; IBA:GO_Central.
DR CDD; cd19815; Bbox1_HOIP; 1.
DR CDD; cd20337; BRcat_RBR_HOIP; 1.
DR CDD; cd16631; mRING-HC-C4C4_RBR_HOIP; 1.
DR CDD; cd10464; PUB_RNF31; 1.
DR CDD; cd20351; Rcat_RBR_HOIP; 1.
DR Gene3D; 1.20.58.2190; -; 1.
DR Gene3D; 6.10.140.1100; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR047543; Bbox1_RNF31-like.
DR InterPro; IPR047540; BRcat_RBR_RNF31-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR036339; PUB-like_dom_sf.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR047542; Rcat_RBR_RNF31-like.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR032065; RNF31-UBA.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR047541; RNF31_RBR_mRING-HC-like.
DR InterPro; IPR057426; RNF31_UBA_3.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR16004:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF31; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 1.
DR Pfam; PF22191; IBR_1; 2.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF16678; UBA_HOIP; 1.
DR Pfam; PF25163; UBA_RNF31; 1.
DR Pfam; PF00641; Zn_ribbon_RanBP; 2.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00547; ZnF_RBZ; 3.
DR SUPFAM; SSF143503; PUG domain-like; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 2.
DR PROSITE; PS50199; ZF_RANBP2_2; 3.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1044 AA; 117751 MW; B43B1CDCC97CD954 CRC64;
MAEHHIRNAL ENVLIHQPGA LTPELLDKML ELPLRERYQR LNAEDLIKGG TQVSRLHSVI
TALNILEKYG RNLLSPLRPK FWRSVKFNNP VFKTTVDAIE GGRFVLSLYG YSQSLPDGLS
FPDSVLEPDV STVAAVTADV IILHYELNLL VSKTHPRQKE AAQELLGGEL PQQSLVADYI
SVSKDPHPAT SDNNKCTETT SAGCFLCGTL ACSVFCCSCN EMLCEECDKR AHSHPARAEH
VRLPCGNTAM ARPVDQGSPS PVSSRPPWKC YSCHFENKGG SILCVECDRP RGCTSSLSNQ
SLGSTLQRDS WECQACTLQN SASAVLCSVC DRPRLASKPT QDGYDSAALL LRDIQRDNKS
ITYPVREGEK AGLSSIKNHQ ENTFETESIG PLIDHTRREE EIAKSEGWQC SHCTFFNTQN
GRVCEICDRA REGTAAAEQP KVLDMHVQEE IRQKQLREDG AKIVALIRKG EKNGVLPEEV
CSAIRYSGTE VPERWLQTEL PYVLERLLDA ASQKARDMVG ALTVEEAREA WVSSGGDMDA
AVILCLTERR RKVDALSTLG FPDKDKVVAA LYESAGDVGR ALSILQKPLL EPFLIRMWEE
SQPPLRLDSA DRQAVLRRLL AEHSLHSWGR AELALSLLLE GEGRYELQDV VEAVRESQDR
DFIKRMLTQE CAVCGWELPR NKMRSLTSCE CCICPDCFRT HFTVAVKEKH IRDMICPACE
APEISNEDEL LHYFSTLDIL LRDTLEVDAY NLFHKKLTER TLMKDPKFLW CTHCSFGFIY
ERDQLDVKCP QCHCSFCRSC KRPWEEQHRS LSCEDFQNWK RENDAEYQAQ GLAVYLQDNG
ITCPHCKFSY ALARGGCMHF ICSQCRHQFC SGCYNTFHPR NKCTVPSCMV RMSLHAHHPR
DCLFYLRDWD VTRLQRLLQM SKVQFNTEPP AGTQTVPGGG CRVVEQKEIP DGLRDEACGK
VTSPGYAGLC ESHYKEYLVS RINARSLDPC VLYDLAETVN VCQRYLPLLP LQDLNEDEAS
YKERLLGVLM SEVPLSLNIP RKQH
//
