ID A0A1M6BQW2_9RHOB Unreviewed; 360 AA.
AC A0A1M6BQW2;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00013014};
DE EC=1.1.1.169 {ECO:0000256|ARBA:ARBA00013014};
DE AltName: Full=Ketopantoate reductase {ECO:0000256|ARBA:ARBA00032024};
GN ORFNames=SAMN05444417_0804 {ECO:0000313|EMBL:SHI51109.1};
OS Wenxinia saemankumensis.
OC Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC Rhodobacterales; Roseobacteraceae; Wenxinia.
OX NCBI_TaxID=1447782 {ECO:0000313|EMBL:SHI51109.1, ECO:0000313|Proteomes:UP000184292};
RN [1] {ECO:0000313|EMBL:SHI51109.1, ECO:0000313|Proteomes:UP000184292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 100565 {ECO:0000313|EMBL:SHI51109.1,
RC ECO:0000313|Proteomes:UP000184292};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
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DR EMBL; FQYO01000002; SHI51109.1; -; Genomic_DNA.
DR RefSeq; WP_073326551.1; NZ_FQYO01000002.1.
DR AlphaFoldDB; A0A1M6BQW2; -.
DR STRING; 1447782.SAMN05444417_0804; -.
DR OrthoDB; 9793586at2; -.
DR Proteomes; UP000184292; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:TreeGrafter.
DR GO; GO:0050661; F:NADP binding; IEA:TreeGrafter.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR050838; Ketopantoate_reductase.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000184292}.
FT DOMAIN 4..156
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 182..333
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 360 AA; 39264 MW; DFBE5C6B5725B17D CRC64;
MKFTIIGSGA IGGLAGAWMT EAGHDVTLVD RWAEHVAAMN ESGLRIDGVR GDKHVAVKAA
TPDQLTGELG VVLIATKSQH AVEAVEDIAP LLTPESCVVS FQNGFNEPDL VAALDAAGLP
GERMVMGSIP NYGGALVDPG EIEFVHEGPI QLGEMDGAMS DRLKDIAEAL SALTEVQVSD
RIWGQIWAKE VYASQVVFSA LVDAPIREAL GNERYARIAG AIVKEALEIA DANGIDVQPF
DFFDPANYRV RTAEDTRKLL DNVNHAIWLL KKDQDTKPQH DFKKKGSGIW WDIVYRKRPS
ETRSSSGKLI AYGEAVGADT RLNAKLFEMI YEIEDGRREL GFHNYDELEA YVAECGKTLP
//
