ID A0A1N7BZD6_9ACTN Unreviewed; 584 AA.
AC A0A1N7BZD6;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 28-JAN-2026, entry version 36.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN05444858_11216 {ECO:0000313|EMBL:SIR56672.1};
OS Micromonospora avicenniae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1198245 {ECO:0000313|EMBL:SIR56672.1, ECO:0000313|Proteomes:UP000186004};
RN [1] {ECO:0000313|EMBL:SIR56672.1, ECO:0000313|Proteomes:UP000186004}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45758 {ECO:0000313|EMBL:SIR56672.1,
RC ECO:0000313|Proteomes:UP000186004};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FTNF01000012; SIR56672.1; -; Genomic_DNA.
DR RefSeq; WP_076471703.1; NZ_FTNF01000012.1.
DR AlphaFoldDB; A0A1N7BZD6; -.
DR STRING; 1198245.SAMN05444858_11216; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000186004; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SIR56672.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000186004}.
FT DOMAIN 1..167
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 584 AA; 61643 MW; 51A66C87DB5CADD8 CRC64;
MWVVATAGHV DHGKSTLVRA LTGMEPDRWA EERRRGMTID LGFAWATMPS GGTVAFVDVP
GHERFVPNML AGVGPAPAAL IVVAADEGWM PQSAEHLAAL HALGVSYGLL AVTRADLADP
HPAMAQARTQ IAGTTLGAVE AVAVSALTGA GLPELRAALD RLAARLPAPA RDGPVRLWVD
RSFTIRGSGT VVTGTLGAGR LRVGDELELA GTGESVRVRG LQTLGSATSE VTAVARVAVN
LRGTPRDRLT RGDALLSPGR FHRTEVVDVR VAGDPAVELP ATLTLHVGSA AVPVRVRPLG
ADTARLRLAR PLPLLVGDRA LLRDPGRHHV AGGVIVLDVA PPALTRRGAA GARADVLAGL
DGRADLAGEL GRRRLVRAAD LIRMGVPVDV APVAGDWLAD PGHWRQLGAR LAEEVARHGR
EHPLEPGAPV EMLRQRLMLP DRVLVEALVR PPLRLLGGRV TAAAVDALPD PVARAVRRIR
DEYGHRPFQA PEADRLADLG LGPREIGAAV RAGALLRLAE NVVLLPEVLD DAVRVLAGLP
QPFTLSAARR ALDTTRRVAV PLLELLDRRG ATRRLPDDAR IVVG
//
