ID A0A1N7PT03_9BACL Unreviewed; 637 AA.
AC A0A1N7PT03;
DT 15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2017, sequence version 1.
DT 28-JAN-2026, entry version 32.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=SAMN05421790_11462 {ECO:0000313|EMBL:SIT13783.1};
OS Kroppenstedtia eburnea.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales;
OC Thermoactinomycetaceae; Kroppenstedtia.
OX NCBI_TaxID=714067 {ECO:0000313|EMBL:SIT13783.1, ECO:0000313|Proteomes:UP000186795};
RN [1] {ECO:0000313|Proteomes:UP000186795}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45196 {ECO:0000313|Proteomes:UP000186795};
RA Varghese N., Submissions S.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FTOD01000014; SIT13783.1; -; Genomic_DNA.
DR RefSeq; WP_084190213.1; NZ_CP048103.1.
DR AlphaFoldDB; A0A1N7PT03; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000186795; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:SIT13783.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000186795}.
FT DOMAIN 3..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 637 AA; 70640 MW; C287599A9ED866C0 CRC64;
MEPKRYVIGT AGHIDHGKTM LTRVLTGVNT DRLKEEQERN ISIEPGFAPL TLPSGLTVSI
IDVPGHEKLI RQMVAGVAGI DFVLLVVAAD EGVMPQTREH LSILDLLGVK NGLLLLSKID
RADPDLLPII EEDLRGLTRG TFLEGAPLLR ISSATGEGID HLLQVLDEKL PCIEQRKSEA
PFRLPVDRSF IVKGAGTVVT GTVQSGSTGP GEELEVLPGG KRVKVRQAQV HSQTVPIVQA
GQRAALNLSG INREEVFRGQ TVVQPGIWST SRRIDIRAVS LPELDFSLRQ RSLVTLMIGT
SEVFAELILY DRKEWKPGEE IYASLVLREP VVAAHGERFI LRRPTPATTI GGGEVAEAAA
LKRKISPASA EEIRQVWVGG LTARILRALD RTLLLTFREI QSVSGEGEAT LHAELKALEE
AGRILPVASG FASVNTLTRI GEEMTDWLIS YHREHPMIPG VPKAEWSARF LPDLDTKEVN
TLLAMWEKRR MLIQRGEYIS LHSFTPDLPA RWKPAVAQVM NRLQREGWTP TEWETLLQEA
GIPAKPGEDI RGYLIREATL VPLTEKLLMH REAYDRAVDL AAKTIRREGS LSMQLAKECF
GLSRKYLVPL LELMDKKGIT RRVGDKRILI QEEKASR
//
