ID A0A1S1HJT2_PROST Unreviewed; 622 AA.
AC A0A1S1HJT2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 28-JAN-2026, entry version 33.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=A3Q29_10525 {ECO:0000313|EMBL:OHT22554.1};
OS Providencia stuartii.
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Enterobacterales; Morganellaceae; Providencia.
OX NCBI_TaxID=588 {ECO:0000313|EMBL:OHT22554.1, ECO:0000313|Proteomes:UP000179588};
RN [1] {ECO:0000313|EMBL:OHT22554.1, ECO:0000313|Proteomes:UP000179588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Crippen {ECO:0000313|EMBL:OHT22554.1,
RC ECO:0000313|Proteomes:UP000179588};
RA Yuan Y., Zhang Y., Fu S., Crippen T.L., Visi D., Benbow M.E., Allen M.,
RA Tomberlin J.K., Sze S.-H., Tarone A.M.;
RT "Genome sequence of Providencia stuartii strain, isolated from the salivary
RT glands of larval Lucilia sericata.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OHT22554.1}.
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DR EMBL; LVIE01000223; OHT22554.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1S1HJT2; -.
DR Proteomes; UP000179588; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0035368; F:selenocysteine insertion sequence binding; IEA:TreeGrafter.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:TreeGrafter.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR GO; GO:0016259; P:selenocysteine metabolic process; IEA:TreeGrafter.
DR CDD; cd04171; SelB; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050543; eIF2G.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR048649; WHD_1st_3rd_SelB.
DR InterPro; IPR048931; WHD_2nd_SelB_bact.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR42854; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER; 1.
DR PANTHER; PTHR42854:SF3; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF21458; WHD_1st_3rd_SelB; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF21214; WHD_2nd_SelB_bact; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000179588}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 622 AA; 69905 MW; D2D0935F6FBEBB41 CRC64;
MIFATAGHVD HGKTTLIKAI TGVNTAHLPE EKKRGMTIDL GYAYWPQPDG SSIGFIDVPG
HEKFLGNMLA GVGGINHALL VVACDDGVMA QTREHLAILR LAGCQCVTAV LTKADRVDEQ
RVTEVALDVE AELHRQGWFD TPLFITAANE GRGIPELQTY LQQLHQKTAD HQNQQQRFRL
AIDRVFHVKG AGIVVTGTAL AGKVALNEPL WLTGADSVVR VRGIHRQNQQ SEFAQAGDRV
ALNLAGDIDK TNITRGDWLL SEKPFAAATR VIVELTCDSV IKHWQPVHLY HGASHITGRV
SLLTEQGKAP LLAELILDTP LWLVDDDRLI LRDISARETL ASARVIRLVS PRRGKRQPEF
IEWLRSLCAA KDELSHLKLQ LPNGELDLNG YGWSRQLTSY ALENLLSQVE LVRVGNLALS
AFKAQVAKER LVQILEDFHE VHSDQIGVSK ARLKRMALPT MSESLVFKLI NELLIDERIK
QTRGWLHMPQ HGLVFDREQQ QIWQQVSGLF PRVDAWWVRD LAAETKHDEG VLRSVMKKAA
QMGLVTAIVR DRYYSREQIE QFAELILHYC IEKGAITAAD FRNELGVGRK LAIQILEFFD
KSGFTRRKGD EHFLRDKDIF IE
//
