ID   A0A1S2ZTX6_ERIEU        Unreviewed;       684 AA.
AC   A0A1S2ZTX6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   28-JAN-2026, entry version 32.
DE   RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN   Name=ZNF750 {ECO:0000313|RefSeq:XP_007524504.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP001652624, ECO:0000313|RefSeq:XP_007524504.1};
RN   [1] {ECO:0000313|RefSeq:XP_007524504.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (AUG-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_007524504.1; XM_007524442.2.
DR   AlphaFoldDB; A0A1S2ZTX6; -.
DR   FunCoup; A0A1S2ZTX6; 55.
DR   STRING; 9365.ENSEEUP00000008102; -.
DR   GeneID; 103114719; -.
DR   CTD; 79755; -.
DR   eggNOG; ENOG502QU7X; Eukaryota.
DR   InParanoid; A0A1S2ZTX6; -.
DR   OrthoDB; 8933073at2759; -.
DR   Proteomes; UP001652624; Chromosome 14.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008544; P:epidermis development; IEA:TreeGrafter.
DR   InterPro; IPR039363; ZNF750.
DR   InterPro; IPR039064; ZNF750_Znf.
DR   PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR   PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR   Pfam; PF15269; zf-C2H2_7; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP001652624};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          6..57
FT                   /note="Zinc finger protein 750-like zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF15269"
FT   REGION          66..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..94
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..400
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..583
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..601
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  72975 MW;  1F9B83524D54CB8E CRC64;
     MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
     RIPKCPKSQA SALDPKQVSP ADPTAKATSS KAAANGLGHF DPRLHGLAQE DLKENLELRV
     RGTHKGLGQK PIPHKEIMPP SQVADTALGP PQPLLEGVVR PSAFVPVGEH RLKGPEPPEG
     PEALALPGPA AKAGAFHSKS AFHAPGYPWK AGSPFLSPEF PPKVPPAKGF GAVSPFLHPA
     IPEYSPHFYT EHGLATIYSP YLLTGAAAEC DTPLLSVYGG QDQRHFLPHP GALPKHVGPS
     AAYDHYRFFQ QYHPSLPLPY SFYRPDSAFS SYGLRLPPMS GLGREPGTHL LEEATLAYPA
     SSPAKANPPG THKRHPEFEK QSPTPEANDL SKDGQRDTEG AKMSPRAGSA ATGSPGRPSP
     TNFTQTGQAC PELCGGPNKA GPGILGRLLP TEHSPTAFQP IKRSTDHTQP QVLANGTQSP
     ESLSSAGPEV LARPGSTTPG TEAPASPEDS SRIAPLNLST RGEPGPGGPQ DFPELQDMPL
     NLSVRDPCNA LASHPVHSPP PKAEPEAPAQ KVDPKEPEAH MEEAAPGAPT RKTLDSSEEQ
     KQTAAVALCQ LATYSPGNPR PGDGEPTAPQ EDTPTSQEAA GDPRPRGQKR TSPREAGKAQ
     QGSKKTKASG TARVFMLRKR TRVS
//